1,4-BIS(2-HYDROXYETHYL)PIPERAZINE,CAS 122-96-3

SHANGHAI PROVCHEM INDUSTRIAL CO., LTD., RELYING ON SICHUAN WILLOW GREEN BIOTECHNOLOGY CO., LTD. AND SHANXI WILLOW GREEN BIOTECHNOLOGY CO., LTD., IS A BIOTECHNOLOGY ENTERPRISE INTEGRATING THE RESEARCH AND DEVELOPMENT, PRODUCTION AND SALES OF COSMETIC RAW MATERIALS, APIS, PHARMACEUTICAL INTERMEDIATES, PESTICIDES, AND AMINO ACIDS. THE COMPANY IS LOCATED IN OFFICE 2925, BUILDING 1, DANING MUSICAL PLAZA, NO.1 LANE 177, WANRONG ROAD, SHANGHAI. IT IS ONE OF THE FEW COMPANIES IN CHINA WITH THE QUALIFICATIONS AND PROCEDURES FOR WARANG CYANIDE AND SODIUM AZIDE.

SINCE ITS ESTABLISHMENT IN 1998, THE FACTORY HAS EXPANDED TO MORE THAN 20,000 SQUARE METERS, WITH A TOTAL INVESTMENT OF MORE THAN 200 MILLION YUAN AND AN ANNUAL OUTPUT VALUE OF MORE THAN 500 MILLION YUAN. THE FACTORY HAS COMPLETE SUPPORTING FACILITIES SUCH AS A SPECIAL CHEMICAL WAREHOUSE, A WELL-EQUIPPED QUALITY INSPECTION DEPARTMENT, A RESEARCH AND DEVELOPMENT TEST DEPARTMENT, AND ENVIRONMENTAL PROTECTION TREATMENT FACILITIES. AT THE SAME TIME, IT HAS MORE THAN 150 EMPLOYEES, INCLUDING 30 MANAGEMENT PERSONNEL, 20 QUALITY INSPECTION PERSONNEL, AND TECHNICAL PERSONNEL ACCOUNT FOR ABOUT 30% OF THE TOTAL NUMBER OF EMPLOYEES. RELYING ON THE EXPERIENCED PROCESS RESEARCH AND DEVELOPMENT, PRODUCTION MANAGEMENT AND MARKETING TEAM IN THE BIOPHARMACEUTICAL INDUSTRY, THE COMPANY MAINTAINS CLOSE RESEARCH AND DEVELOPMENT COOPERATION WITH THE PHARMACEUTICAL AND CHEMICAL ENGINEERING COLLEGES OF MANY UNIVERSITIES IN SHANGHAI, SICHUAN AND SHANXI PROVINCE, CONTINUOUSLY IMPROVING THE SCIENTIFIC AND TECHNOLOGICAL CONTENT OF PRODUCTS AND ENSURING THE ADVANCED NATURE OF RESEARCH AND DEVELOPMENT TECHNOLOGY.

AS A TRUSTWORTHY PARTNER, OUR HIGH-VALUE PRODUCTS CAN HELP CUSTOMERS ACHIEVE GREATER SUCCESS. WE HAVE MAINTAINED LONG-TERM COOPERATIVE RELATIONS WITH WELL-KNOWN DOMESTIC PHARMACEUTICAL COMPANIES FOR MANY YEARS. AT THE SAME TIME, EXCELLENT QUALITY, COMPETITIVE PRICES, A VARIETY OF DELIVERY AND PAYMENT METHODS, SINCERE AND TIMELY SERVICE ALSO ENABLE US TO HAVE A LONG-TERM CUSTOMER BASE IN THE UNITED STATES, RUSSIA, THE MIDDLE EAST, PAKISTAN, SOUTH KOREA, CHILE AND OTHER COUNTRIES AND REGIONS.

1,4-Piperazinediethanol Use and Manufacturing
Methods of Manufacturing
Preparation of 1, 4-bis(hydroxyethyl)piperazine from diethanolamine (no solvent)was carried out under the conditions of in the same apparatus. 100 g of diethanolamine (II) and 10 g of catalyst A were used. Gas chromatographic analysis (GC column: 30 m RTX Amin) indicated, at quantitative diethanolamine conversion, that the reaction output comprised 79percent of 1, 4-bis(hydroxyethyl)piperazine.Under a nitrogen atmosphere, the reactor 100 ml, piperazine 8.6 g (0.1 mol) g of methanol 10.4 g, was added while stirring 35percent hydrochloric acid 10.4 g (0.1 mol), internal temperature It was referred to as 80 ° C. There, while maintaining the internal temperature below 80 ° C, 2- bromoethanol 8.7g of (0.07 mol) was added dropwise over 0.5 hours and then further continued for 2 hours and stirring remains the same temperature conditions. Since the reaction liquid was 4.2 where pH was measured, and added of 25percent NaOH aqueous solution 7.6 g, and the pH was adjusted to 8.5. Furthermore, maintaining the internal temperature at 80 ° C, stirring was continued for 2 hours to obtain a reaction solution 36.2g of colorless and transparent. Results The product was analyzed by gas chromatography, is 86.2percent for a yield of N-(2-hydroxyethyl) piperazine, the selectivity, N-(2-hydroxyethyl) piperazine, 91.9percent, N, N'- bis (2-hydroxyethyl) piperazine is 6.7percent, unknown content was 1.4percent. Along with other examples showing the results of Example 8 shown in Table 1.

Uses
Processing aids, specific to petroleum production