In Stock Survodutide | 99% High Purity | 5mg/Vial | Wholesale Price

Core Mechanism of Action

• GLP‑1R activation:

  
  

  Centrally suppresses appetite and delays gastric emptying to reduce energy intake;

  
  

  Stimulates insulin secretion and inhibits glucagon secretion in a glucose‑dependent manner to improve glucose metabolism.
  
  
• GCGR activation:

  
  

  Directly promotes fatty acid oxidation in hepatocytes and reduces hepatic lipid synthesis and accumulation;

  
  

  Activates lipolysis in adipose tissue, increases thermogenesis and energy expenditure;

  
  

  Upregulates hepatic gluconeogenesis and glycogenolysis to maintain glucose stability.
  
  
• Synergistic effects:

  
  

  Drives “reduced intake + increased consumption” for greater weight loss than single‑target GLP‑1 agonists;

  
  

  Acts directly on the liver to improve inflammation and fibrosis in MASH, with some effects independent of weight loss.
  
  

Pharmacokinetic and Structural Features

• Long‑acting design: C18 diacid‑mediated albumin binding extends half‑life, supporting once‑weekly subcutaneous administration.
• Stability: Resists DPP‑4 hydrolysis, greatly improving stability and half‑life in vivo.
• In vitro activity: The agonistic activity ratio for GLP‑1R and GCGR is approximately 1:8.

Clinical Indications

• Obesity / overweight (Phase III SYNCHRONIZE™‑1/2), type 2 diabetes, and metabolic dysfunction‑associated steatohepatitis (MASH).
• Key advantages: balanced glycemic control and weight loss, direct improvement of liver fibrosis, and a trend toward reduced all‑cause mortality.

Peptide Storage Guidelines: General Tips

When storing peptides, remember to:
• Store peptide in a cold, dry, dark place
• Avoid repeated freezing and thawing of peptide
• Avoid overexposure to the air
• Avoid light exposure
• Avoid storing peptides in solution long term
• Aliquot peptide according to experimental requirements

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