IGF-1 LR3 CAS: 946870-92-4 Raw materials Wholesale price Reduced weight peptide 99% purity Factory direct sale Safe delivery

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  IGF‑1 LR3: Professional Product Description

  
  

  IGF‑1 LR3 (Long Arginine3‑Insulin‑Like Growth Factor 1) is a synthetic, long‑acting variant of human Insulin‑Like Growth Factor 1 (IGF‑1), engineered with a modified amino acid sequence to enhance stability, extend half‑life, and improve biological activity in vivo.

  
  

  Core Characteristics & Mechanism of Action

  
  

  • Structural Modification: Compared to native IGF‑1, IGF‑1 LR3 features a substitution of arginine for glutamic acid at position 3 (LR3 mutation), which significantly reduces its binding affinity to IGF‑binding proteins (IGFBPs).
  • Prolonged Activity: The reduced BP binding results in a much longer circulating half‑life (approximately 20–30 hours) compared to endogenous IGF‑1 (minutes to hours), enabling sustained biological effects with less frequent administration.
  • Primary Mechanism: As a potent agonist of the IGF‑1 receptor (IGF‑1R), it stimulates cell proliferation, differentiation, and survival, while also promoting protein synthesis, glucose uptake, and lipid metabolism regulation.

  
  

  Key Biological Functions

  
  

  1. Muscle Growth & Regeneration: Promotes hypertrophy of skeletal muscle fibers, enhances myoblast proliferation and fusion, and supports tissue repair and recovery—making it widely studied in muscle physiology and regenerative medicine.
  2. Metabolic Regulation: Modulates carbohydrate and lipid metabolism, increasing insulin sensitivity in peripheral tissues (e.g., muscle and adipose tissue) and facilitating the uptake of glucose and amino acids to support anabolism.
  3. Anti‑Catabolic Effects: Inhibits apoptosis of muscle cells and reduces breakdown of muscle tissue, which is valuable in contexts of muscle wasting or recovery from injury/illness.

  
  

  • Appearance: Powder

    • Purity: >99% (or refer to the Certificate of Analysis)

      Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

      Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

      Solubility: To be determined

      Shelf Life: >2 years if stored properly

      Drug Formulation: To be determined

      Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

      HS Tariff Code: 2934.99.9001

      Peptide Storage Guidelines: General Tips

      Name	IGF-1 LR3
      CAS RN	946870-92-4
      Storage Condition	-20°C
      Appearance	Powder
      EINECS	1592732-453-0

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  • • • When storing peptides, remember to:

        • Store peptide in a cold, dry, dark place
        • Avoid repeated freezing and thawing of peptide
        • Avoid overexposure to the air
        • Avoid light exposure
        • Avoid storing peptides in solution long term
        • Aliquot peptide according to experimental requirements

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  We are a chemical manufacturer integrating production, processing and export, mainly dealing in pharmaceutical intermediates and various industrial chemicals. Since its establishment, the company adheres to the spirit of "integrity management, strict quality control, customer first", and has won praise from customers at home and abroad.  We have also established an excellent professional sales team with rich international marketing experience, able to efficiently provide a range of products and professional services.

    With synthetic biology platform technology as the core, it conducts innovative research and development, mainly engaged in the research and development of recombinantly expressed pharmaceutical peptides and proteins. Its products include innovative drugs, APIs, pharmaceutical and green synthetic industrial enzymes, functional peptides and protein products, etc.

    At present, our company has realized the industrialization of a variety of biosynthetic peptide products and has obtained cooperation orders from many well-known domestic and foreign pharmaceutical companies.

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