Testagen (KEDG Tetrapeptide) Full Detailed Product Description
Product Overview
Testagen, also coded as KEDG, is a synthetic tissue-specific tetrapeptide bioregulator developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. Its full amino acid sequence is Lysine-Glutamic Acid-Aspartic Acid-Glycine (H-Lys-Glu-Asp-Gly-OH). It is the synthetic active analog of natural testicular extract Testoluten, specially designed to regulate male reproductive endocrine system and support testicular cellular function at the genetic level.
Basic Technical Specifications
- Sequence: Lys-Glu-Asp-Gly (KEDG)
- CAS Number: 1026993-38-3
- Molecular Formula: C₁₇H₂₉N₅O₉
- Molecular Weight: 447.44 Da
- Purity: ≥99% (HPLC verified, low single impurity)
- Appearance: White sterile lyophilized powder
- Solubility: Fully soluble in distilled water and 0.9% benzyl alcohol bacteriostatic water
- Standard Packaging: 5mg / 10mg / 20mg sterile sealed vials
- Quality Documents: Complete COA, HPLC chromatogram, mass spectrum test report provided per batch
- Shelf Life: 24 months under standard long-term storage
- Storage Conditions: Long-term sealed storage at -20°C, away from light, moisture and repeated freeze-thaw cycles; reconstituted solution stored at 2–8°C within 7 days
Mechanism of Action
- Epigenetic Gene Regulation via DNA Binding
As an ultra-short peptide bioregulator, Testagen can penetrate cell membranes and enter the nucleus, directly binding to chromatin and target DNA fragments of testicular tissue. It modulates transcription of steroidogenic genes including StAR, CYP11A1 and 3β-HSD to balance hormone synthesis without exogenous hormone supplementation. - Activate Leydig & Sertoli Cells
It targets testosterone-producing Leydig cells and spermatogenic Sertoli cells in testis tissue, restoring cellular metabolism and improving the natural testosterone biosynthesis pathway. - Optimize HPG Axis Signaling
Rebalances the hypothalamic-pituitary-gonadal (HPG) endocrine feedback loop, enhances gonadotropin signal transmission, and alleviates age-related endocrine decline in male reproductive system. - Anti-Inflammatory & Reproductive Tissue Protection
Suppresses inflammatory cytokines in reproductive tissues, reduces chronic mild inflammation of prostate and testis, and protects testicular cells from oxidative aging damage. - Auxiliary Thyroid & Immune Modulation
Dual-regulates pituitary-thyroid axis function to stabilize thyroid hormone levels, and moderately improves systemic immune activity in aging research models.
Core Research Applications
- Study on age-related testosterone decline and male endocrine aging
- Preclinical research of testicular cell regeneration and spermatogenesis
- Experimental models of hypothalamic-pituitary-gonadal axis imbalance
- Research on chronic testicular inflammation and prostate mild lesions
- Anti-aging gerontology & organ-specific peptide bioregulation experiments
- Endocrine metabolism and thyroid hormone balance related laboratory studies
Product Advantages
- Organ Tissue Specificity
Only targets testicular and pituitary endocrine tissue, no widespread off-target effects compared with general hormone regulators. - High Purity & Stable Batch Consistency
Strict full-process synthesis and purification, endotoxin controlled to meet laboratory injection experiment standards, consistent purity across all batches. - Excellent Solubility & Stability
Lyophilized powder avoids degradation during transportation; reconstituted liquid maintains stable activity for short-term laboratory use. - Verifiable Lab Test Reports
Each batch supports full set of traceable test documents, matching customers’ third-party testing filing demands.
Important Disclaimer
This product is for laboratory research use only. It is not approved for human clinical treatment, oral consumption, injection therapy, food, cosmetic or veterinary application. All experimental data are limited to preclinical in vitro and animal model studies. Operate strictly following laboratory safety operation specifications.
Short Listing Bullet Points (for product page)
- Testagen (KEDG) tetrapeptide bioregulator, sequence Lys-Glu-Asp-Gly
- ≥99% HPLC high purity, white sterile lyophilized powder
- Tissue-specific testicular peptide, regulates testosterone synthesis & HPG axis
- Activates Leydig cells, supports male reproductive endocrine research
- Anti-inflammatory, anti-aging effects for gerontology & endocrine lab study
- Fully soluble in bacteriostatic water, multiple vial specifications available
- Complete COA, HPLC & MS test reports supplied for every batch
- Long-term storage at -20°C, 24-month shelf life
- For laboratory research only, not for human use
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