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Chrysin

Name: Chrysin
Brand: Cuicheng Bio
SKU: pr2606011588
Price: 10 USD
Availability: InStock

2 Inquiries

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CAS No.:

480-40-0

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-03

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information
Inquiry History

Description

Chrysin (CAS Number: 480-40-0) is a natural dihydroxyflavone compound found abundantly in propolis, honey, and passion flowers (Passiflora). It functions as a highly active, multi-target research tool, most notable for its unique ability to modulate endocrine pathways, alongside potent antioxidant, anti-inflammatory, and antitumor properties.

Key Pharmacological Functions and Mechanisms

Natural Aromatase Inhibition (Hormone Regulation): In endocrinology and sports physiology models, chrysin's most distinctive function is acting as a competitive aromatase inhibitor. It binds to the aromatase enzyme to prevent the conversion of androgens (like testosterone) into estrogens (like estradiol). It is widely researched as a natural agent to maximize free testosterone levels and prevent age-related hormone loss.
Targeted Anti-Inflammatory and Anti-Allergic Action: It serves as a potent anti-inflammatory by blocking the NF-$\kappa\text{B}$ signaling pathway and suppressing the phosphorylation of MAPKs (p38 and JNK). This downregulates inducible enzymes (iNOS and COX-2), significantly reducing the release of pro-inflammatory cytokines (such as TNF-$\alpha $, IL-6, and IL-1$\beta $). It also limits histamine release from mast cells, showing effectiveness in models of allergic rhinitis and asthma.
Antitumor Activity and Chemosensitization: In tumor biology, chrysin exhibits cytotoxicity against several cancer cell lines, including breast, prostate, colorectal, and leukemia cancers. It triggers p53-dependent cell cycle arrest (typically at the G1 or G2/M phase) and forces mitochondrial apoptosis by decreasing the Bcl-2/Bax ratio. Furthermore, it downregulates P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), helping to reverse multidrug resistance and act as a chemosensitizer.
Robust Antioxidant and Organ Protection: Chrysin features excellent radical scavenging capabilities. It actively stimulates the Nrf2/ARE signaling pathway, which elevates intracellular glutathione (GSH) and upregulates protective enzymes like superoxide dismutase (SOD) and heme oxygenase-1 (HO-1). This shields critical organs against severe chemotherapy-induced nephrotoxicity (kidney damage) and hepatotoxicity (liver damage).
Neuroprotection and Anxiolytic (Anti-Anxiety) Support: It readily crosses the blood-brain barrier to interact with the benzodiazepine-binding site of the $\text{GABA}_{\text{A}}$ receptor, functioning as a mild, natural anxiolytic and sedative without causing common drug side effects like muscle relaxation or motor impairment. It also curbs microglial over-activation to slow down neurodegenerative damage.
Metabolic and Lipid Homeostasis: Chrysin activates the AMPK signaling pathway to regulate total fat metabolism. It reduces hepatic lipogenesis (fat accumulation in the liver), improves peripheral insulin sensitivity, and helps correct high blood glucose levels caused by high-fat diets.

Industrial and Quality Control Functions

Propolis and Honey Biomarker: Because chrysin concentrates specifically within high-quality bee products, analytical testing laboratories utilize it as a definitive HPLC reference standard to determine flavone profiles, assess the purity of raw materials, and authenticate commercial honey or propolis supplements.

Basic Info

Product Name:

Chrysin

Other Name:

4H-1-Benzopyran-4-one,5,7-dihydroxy-2-phenyl-;Chrysin;Flavone,5,7-dihydroxy-;5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one;5,7-Dihydroxyflavone;NSC 407436;Crysin;5,7-Dihydroxy-2-phenylchromen-4-one;5,7-Dihydroxy-2-phenyl-4H-chromen-4-one

CAS No.:

480-40-0

Molecular Formula:

C15H10O4

InChIKeys:

InChIKey=RTIXKCRFFJGDFG-UHFFFAOYSA-N

Molecular Weight:

254.24

Exact Mass:

254.24

BRN:

233276

EC Number:

207-549-7

UNII:

3CN01F5ZJ5

NSC Number:

407436

DSSTox ID:

DTXSID1022396

HScode:

2914400090

Categories:

Skin Conditioning

Characteristics

PSA:

66.8

XLogP3:

2.1

Appearance:

Yellow Crystalline Powder

Density:

1.4±0.1 g/cm3

Melting Point:

285.5 °C

Boiling Point:

491.9°C at 760 mmHg

Flash Point:

192.5±22.2 °C

Refractive Index:

1.699

Water Solubility:

84 mg/L @ 25 °C (est)

Storage Conditions:

0-6°C

Collision Cross Section:

151.7 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

See More Chrysin Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Chrysin Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Turkey	Chrysin	10 KG	Jul 17, 2024
India	Chrysin	3	Aug 6, 2024

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Chrysin

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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