 Home > Chemical Reagents > Organic Reagents > 5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester for Sale > 5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester

5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester

Name: 5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester
Brand: Cuicheng Bio
SKU: pr2606011651
Price: 70 USD
Availability: InStock

Unit Price:

$70-80/G FOB

Get Latest Price 

CAS No.:

105544-30-7

Grade:

Industrial Grade

Content:

98%

Port:

guanghzou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-02

Contact Supplier

 Chat Now

Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

 Visit Store

Product Description
Seller Information

Description

5-Bromo-1H-pyrazolo[3,4-c]pyridine functions primarily as a highly valuable heterocyclic core scaffold and pharmaceutical intermediate in modern drug discovery, particularly in Fragment-Based Drug Discovery (FBDD). Its core roles in organic synthesis and drug design can be detailed as follows:

1. Core Scaffold for Kinase Inhibitor Design

The bicyclic system (a pyrazole ring fused with a pyridine ring) highly mimics the core structure of natural purines or other bio-active molecules. In medicinal chemistry, it is widely utilized to develop kinase inhibitors targeting malignancies, such as compounds targeting oncogenic or immunodeficient-related proteins like ERK2, Pim kinases, or Protein Kinase B (PKB).

2. Precise Vectorial Functionalization

According to literature in chemical journals, this compound possesses excellent potential for late-stage multi-site chemical modification. It allows researchers to extend side chains into different spatial directions (growth vectors) while maintaining the core scaffold:

The C-5 Position (Bromine-substituted site): This is the most critical functional site of the molecule. Through transition-metal-catalyzed Buchwald–Hartwig amination or Suzuki–Miyaura cross-coupling reactions, the bromine atom can be efficiently replaced with diverse aryl or amino groups to significantly enhance target affinity.
The N-1 and N-2 Positions (Pyrazole nitrogens): These sites can be selectively modified via protection reactions or N-alkylation to balance the lipophilicity and metabolic stability of the final drug molecule.
The C-3 Position: Advanced groups can be introduced through tandem borylation.

3. Rapid Evolution from "Fragment" to "Lead Compound"

In the pharmaceutical industry and biochemical laboratories, it is treated as a highly efficient building block. Instead of synthesizing the complex bicyclic ring from scratch, medicinal chemists leverage the reactivity of its various positions to rapidly construct diverse chemical libraries. This drastically shortens the R&D cycle from initial fragment hits to optimized lead compounds.

Items	Specifications

Basic Info

Product Name:

5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester

Other Name:

Ethyl 2-((5-bromo-3-nitropyridin-2-yl)oxy)acetate;Ethyl 2-[(5-Bromo-3-nitro-2-pyridyl)oxy]acetate;ETHYL 2-(5-BROMO-3-NITROPYRIDIN-2-YLOXY)ACETATE;ethyl 2-(5-bromo-3-nitropyridin-2-yl)oxyacetate;ETHYL 2-[(5-BROMO-3-NITROPYRIDIN-2-YL)OXY]ACETATE;C9H9BrN2O5;SCHEMBL751950;CTK8C2150;KS-00000QGU;ZINC5585673

CAS No.:

105544-30-7

Molecular Formula:

C9H9BrN2O5

InChIKeys:

UHIILDDDMFTHKM-UHFFFAOYSA-N

Molecular Weight:

305.083

Exact Mass:

303.969482

HScode:

2933399090

Categories:

Organic Reagents

Characteristics

PSA:

94.2

XLogP3:

Density:

1.6±0.1 g/cm3

Boiling Point:

364.1°C at 760 mmHg

Flash Point:

174.0±26.5 °C

Refractive Index:

1.563

See More 5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

Post an enquiry for this product

5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

Related Searches