Foxy-5 | N-Formyl-Met-Asp-Gly-Cys-Glu-Leu Hexapeptide | Wnt5a Mimetic Peptide | CAS No.: 881188-51-8 | For Research Use Only

Foxy-5 More Info

Foxy-5 is a synthetic hexapeptide that functions as a potent mimetic of the Wnt-5a protein, a key signaling molecule involved in embryonic development and cancer progression . Chemically, it is a formylated, six-amino-acid peptide with the sequence For-Met-Asp-Gly-Cys-Glu-Leu-OH (abbreviated MDGCEL) . The compound has a molecular formula of C₂₆H₄₂N₆O₁₂S₂ and a molecular weight of approximately 694.77 g/mol . As a research-grade peptide, it is intended exclusively for laboratory use and is not approved for human therapeutic applications .

The primary mechanism of action for Foxy-5 involves binding to and activating the Wnt-5a receptors Frizzled-2 and Frizzled-5 . This activation triggers a non-canonical Wnt signaling pathway characterized by cytosolic free calcium mobilization, occurring without affecting β-catenin activation or the canonical Wnt pathway . The key biological consequence of this signaling is the inhibition of tumor cell migration and invasion, while importantly, Foxy-5 does not affect cancer cell proliferation or apoptosis . This functional specificity makes Foxy-5 a unique tool for investigating metastasis independently of primary tumor growth.

The discovery and development of Foxy-5 stem from clinical observations that loss of Wnt-5a protein expression in primary breast tumors correlates with faster tumor spread and poorer patient outcomes . Based on this association, researchers hypothesized that reconstituting Wnt-5a signaling could represent a novel anti-metastatic strategy . In preclinical studies, Foxy-5 has demonstrated the ability to impair migration and invasion of breast cancer cells in vitro . Furthermore, in vivo experiments using mouse models showed that administration of Foxy-5 inhibited metastasis from the mammary fat pad to the lungs and liver by 70% to 90% , providing proof-of-principle for this therapeutic approach.

Beyond its direct anti-migratory effects, Foxy-5 has shown potential to restore sensitivity to endocrine therapies in aggressive breast cancer subtypes. Research has demonstrated that Foxy-5 treatment can re-establish estrogen receptor α (ERα) expression in ERα-negative breast cancer cells, both at the mRNA and protein level . This restoration occurs in parallel with reduced methylation of the ERα promoter, and the re-expressed ERα is functional, capable of activating downstream genes and responding to the selective estrogen receptor modulator tamoxifen . These findings suggest that combination therapy with Foxy-5 and tamoxifen could represent a future treatment possibility for patients with ERα-negative breast cancer, a subtype that currently carries a poor prognosis.

For laboratory handling, Foxy-5 is typically supplied as a solid powder with purity ≥95% to ≥98% as verified by HPLC . It is soluble in DMSO at concentrations up to 100 mg/mL (approximately 144 mM) . For long-term storage, the powder should be kept at -20°C, where it remains stable for up to one year, while stock solutions stored at -80°C may remain stable for up to six months . The compound is classified as non-hazardous under GHS (Globally Harmonized System) by some safety data sheets . Foxy-5 has been used in clinical trials investigating treatments for prostate cancer, colorectal cancer, metastatic colon cancer, metastatic breast cancer, and metastatic prostate cancer, with ongoing research exploring its full therapeutic potential .

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.