Top Quality 99% Purity CAS 448944-47-6 Acetyl Hexapeptide-1 repair skin Peptide

Basic Information

• INCI Name: Acetyl Hexapeptide-1
• Common Name: Melitane, Acetyl Hexapeptide-1
• CAS No.: 448944-47-6
• Molecular Formula: C₄₃H₅₈N₁₂O₇
• Molecular Weight: 870.01
• Amino Acid Sequence: Acetyl-Ala-Arg-His-Leu-Phe-Trp-NH₂

Physical & Chemical Properties

• Appearance: White crystalline powder, odorless
• Purity: ≥95%, 98%, 99% available
• Solubility: Easily soluble in water
• Stability: Stable at pH 5-7, heat resistant for normal cosmetic production
• Package: 1g, 10g, 100g, 1kg, 5kg (aluminum foil bag / fiber drum)
• Storage: Store sealed in cool & dry place at 2-8°C
• Shelf Life: 24 months

Mechanism of Action

1. Anti-wrinkle & Expression Line Reduction
   
   
   Inhibits the release of neurotransmitters, relaxes facial muscles and fades dynamic wrinkles such as crow's feet, forehead lines and nasolabial folds.
2. Anti-aging & Skin Firming
   
   
   Activates TGF-β/Smad pathway, boosts synthesis of type I & III collagen, improves skin elasticity and relieves sagging.
3. Anti-glycation & Antioxidation
   
   
   Reduces AGEs formation, prevents collagen cross-linking, scavenges free radicals and brightens dull complexion.
4. Soothing & Repairing
   
   
   Relieves skin inflammation, repairs UV damage and strengthens skin barrier, friendly to sensitive skin.
5. Skin Tone & Hair Care
   
   
   Regulates MC1R receptor to even skin tone and lighten pigmentation; helps improve premature white hair by promoting hair follicle pigmentation.

Efficacy Data

• After 12 weeks of continuous use with 0.0002% addition: Wrinkle depth reduced by 32%, skin elasticity increased by 28%.
• Glycation marker CML decreased by 37%.
• Skin elasticity improved by 30% after 28 days application.
• Non-irritating, non-allergenic and non-comedogenic, safe for long-term use.

Recommended Dosage & Applications

• Anti-wrinkle serum / essence: 0.0001% - 0.001%
• Eye cream / eye mask: 0.0002% - 0.0005%
• Facial cream / lotion: 0.0005% - 0.002%
• Anti-aging mask: 0.0002% - 0.001%
• Sun care & post-procedure repair products: 0.0001% - 0.0005%
• Hair care products (anti-grey hair): 0.001% - 0.01%

Product Advantages

• High activity with low effective dosage, cost-effective for formula.
• Multi-functional effects: anti-wrinkle, firming, brightening and repairing in one ingredient.
• Mild and safe, no hormone, suitable for sensitive skin and pregnant women.
• Excellent compatibility and stability, fits most cosmetic formulations.

Thymosin (also known as thymosine) is a group of polypeptides with physiological activity secreted by the thymus tissue. The commonly used thymosin in clinical practice is a small molecule polypeptide with non-specific immune effects that was discovered and purified from the thymus of a young cow.