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Propionyl chloride79-03-8

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$33-34/MT FOB

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CAS No.:

79-03-8

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-16

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Inquiry History

Description

Product Detail

Propionyl chloride Basic information

Product Name:	Propionyl chloride
Synonyms:	PROPIONYL CHLORIDE FOR SYNTHESIS;AKOS BBS-00004085;Propionyl chloride, 98.5%;PROPIONIC ACID CHLORIDE;Propionyl chloride Propanoyl chloride;PROPIONYL CHLORIDE;PROPANOYL CHLORIDE;Propionyl Chloride Factory Price
CAS:	79-03-8
MF:	C3H5ClO
MW:	92.52
EINECS:	201-170-0
Product Categories:	Acid Halides;Organics;Acid Halides;Carbonyl Compounds;Organic Building Blocks;organic synthesis material;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;API Intermediate;79-03-8;K00001
Mol File:	79-03-8.mol

Propionyl chloride Chemical Properties

Melting point	-94 °C
Boiling point	77-79 °C (lit.)
density	1.059 g/mL at 25 °C (lit.)
vapor density	3.2 (vs air)
vapor pressure	106 hPa (20 °C)
refractive index	n20/D 1.404(lit.)
Fp	53 °F
storage temp.	Store below +30°C.
form	Liquid
color	Clear
PH Range	<7.0
explosive limit	3.6-11.9%(V)
Water Solubility	REACTS
FreezingPoint	-94℃
Sensitive	Moisture Sensitive
Merck	14,7828
BRN	385632
Exposure limits	ACGIH: TWA 0.1 ppm OSHA: TWA 0.1 ppm(0.4 mg/m3) NIOSH: IDLH 2 ppm; TWA 0.1 ppm(0.4 mg/m3); Ceiling 0.2 ppm(0.8 mg/m3)
InChI	1S/C3H5ClO/c1-2-3(4)5/h2H2,1H3
InChIKey	RZWZRACFZGVKFM-UHFFFAOYSA-N
SMILES	CCC(Cl)=O
CAS DataBase Reference	79-03-8(CAS DataBase Reference)
NIST Chemistry Reference	Propanoyl chloride(79-03-8)
EPA Substance Registry System	Propanoyl chloride (79-03-8)

Safety Information

Hazard Codes	F,C
Risk Statements	11-14-34-20/22
Safety Statements	9-16-26-45
RIDADR	UN 1815
WGK Germany	1
RTECS	UG6657000
Autoignition Temperature	270 °C
TSCA	TSCA listed
HazardClass	3
PackingGroup	II
HS Code	29051900
HS Code	29399990
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 3 Inhalation Acute Tox. 4 Oral Eye Dam. 1 Flam. Liq. 2 Skin Corr. 1B
Hazardous Substances Data	79-03-8(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 823 mg/kg

Propionyl chloride Usage And Synthesis

Chemical Properties	Propionyl chloride is a colorless to light yellow, volatile, and readily flammable liquid, whose vapors hydrolyze in moist air. It is corrosive, lachrymatory, and has a strongly pungent odor. With water and lower alcohols it reacts vigorously under solvolysis to give the acid or ester. It is used for the introduction of the propionyl group and for the synthesis of propionate esters because of its high reactivity.
Uses	Propionyl chloride is used as an intermediate in the production of agrochemicals and pharmaceuticals. It serves as an intermediate for dyes, textile auxiliaries and peroxide compounds. It acts as a crop protecting agent.
Preparation	Propionyl chloride is synthesized by reacting propionic acid with phosphorus trichloride at 40-50°C for 1h, cooling, standing, separating and distilling to obtain the product. CH3CH2COOH+PCl3→CH3CH2COCl+HOPCl2 Propionyl chloride is produced industrially by treatment of propionic acid with phosgene or thionyl chloride. The reaction occurs at ca. 50°C in the liquid phase in the presence of dialkylformamides. The product is then separated by distillation. CH3CH2CO2H + COCl2 → CH3CH2COCl + HCl + CO2 Propionyl chloride can also be obtained by the reaction of propionic acid with PCl5.
Application	Propionyl chloride is used for the introduction of the propionyl group and for the synthesis of propionate esters because of its high reactivity. It is an chemical intermediate in the preparation of various propionic acid derivatives, It can also be used: To convert anisole to 4-methoxypropiophenone and 2-methoxynaphthalene to 1-propio-2-methoxynaphthalene in the presence of Indium(III) chloride (InCl3) impregnated mesoporous Si-MCM-41 catalyst. For chlorination in the presence of sulfuryl chloride and peroxides to form α-chloropropionyl chloride and β-chloropropionyl chloride. In reaction with (hydroxypropyl)cellulose to form the propanoate ester, [(propionyloxy)propyl]cellulose.
General Description	Propionyl chloride appears as a colorless liquid with a pungent odor. Corrosive and very irritating to skin and eyes. Used to make other chemicals.
General Description	Propionyl chloride is an important chemical intermediate used to synthesize various propionic acid derivatives.
Air & Water Reactions	Highly flammable. Propionyl chloride reacts vigorously or violently with water to form propionic acid and hydrochloric acid [Merck 11th ed. 1989].
Reactivity Profile	Acid halides, such as Propionyl chloride, are water reactive; some are violently reactive. They are incompatible with strong oxidizing agents, alcohols, amines, and alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Hazard	Strong irritant to skin.
Health Hazard	May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard	Propionyl chloride is a flammable/combustible material.. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Flammability and Explosibility	Highly flammable
Safety Profile	A corrosive irritant to skin, eyes, and mucous membranes. Dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. Reacts with water or steam to produce toxic and corrosive fumes. Exothermic reaction with diisopropyl ether produces much gas. The reaction may be dangerous if confmed. To fight fire, use CO2, dry chemical; do not use water. When heated to decomposition it emits lughly toxic fumes of Cl-. See also HYDROCHLORIC ACID.

Propionyl chloride Preparation Products And Raw materials

Raw materials

Phosphorus pentachloride-->Benzoyl chloride-->Propionic acid

Preparation Products

Propiophenone-->Propionic anhydride-->NAPROANILIDE-->PROPIONYLTHIOCHOLINE IODIDE-->Imidapril-->3-Chloropropionyl chloride-->Tiopronin-->Propanil-->Pimobendan-->Prednicarbate-->ROKITAMYCIN-->1-(2,5-Dimethoxyphenyl)-2-oximino-1-propanone-->Aminoprofen-->Clethodim-->Napropamide-->efficient polymer catalyst for acrylation-synthesis and characterigation of polyamide containing supernucleophilic reagent-->antioxidant 1024-->1-methyl-4-[3,3,3-tris(4-chlorophenyl)propionyl]piperazine-->(4-IODOPHENYL)ACETONE-->2-AMINO-1-(2,5-DIMETHOXYPHENYL)-1-PROPANONE-->4-T-BUTYL PROPIOPHONE-->2-BROMO-1-(6-METHOXY-2-NAPHTHALENYL)-1-PROPANONE-->Ethyl butyrylacetate-->6-Methoxy-2-Acetyl Naphthalene-->Ethyl vinyl ketone-->Ethyl 2-(6-methoxy-2-naphthyl)propanoate

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Basic Info

Product Name:

Propionyl chloride

Other Name:

Propanoyl chloride;Propionyl chloride;Propionic acid chloride;Chloro ethyl ketone;NSC 83547;Propionoyl chloride;Prorionyl chloride;Ethyl chloroform

CAS No.:

79-03-8

Molecular Formula:

C3H5ClO

InChIKeys:

InChIKey=RZWZRACFZGVKFM-UHFFFAOYSA-N

Molecular Weight:

92.52420

Exact Mass:

92.52

EC Number:

201-170-0

UNII:

MB6VL5OMB9

NSC Number:

83547

UN Number:

1815

DSSTox ID:

DTXSID4058819

Color/Form:

Colorless liquid

HScode:

29051900

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

17.07000

XLogP3:

1.16180

Appearance:

Propionyl chloride appears as a colorless liquid with a pungent odor. Corrosive and very irritating to skin and eyes. Used to make other chemicals.

Density:

1.06

Melting Point:

-94 °C

Boiling Point:

80 °C

Flash Point:

11ºC

Refractive Index:

1.402-1.405

Water Solubility:

Solubility in water: reaction.;soluble in ether

Storage Conditions:

Flammables area

Vapor Pressure:

106 hPa (20 °C)

Vapor Density:

3.2 (vs air)

Toxicity:

LD50 orally in Rabbit: 823 mg/kg

Odor:

Pungent odor

Experimental Properties:

Vigorously decomposed and dissolved by water or alcohol|Vigorously reacts with water to form propionic acid and hydrochloric acid. Based on a scenario where the chemical is spilled into an excess of water (at least 5 fold excess of water), half of the maximum theoretical yield of hydrogen chloride gas will be created in 0.09 minutes.|Hydroxyl radical reaction rate constant = 5.9X10-13 cu cm/molec-sec at 25 °C (est)

Air and Water Reactions:

Highly flammable. Vigorously reacts with water to form propionic acid and hydrochloric acid [Merck 11th ed. 1989]. Based on a scenario where the chemical is spilled into an excess of water (at least 5 fold excess of water), half of the maximum theoretical yield of Hydrogen Chloride gas will be created in 0.09 minutes. Experimental details are in the following: "Development of the Table of Initial Isolation and Protective Distances for the 2008 Emergency Response Guidebook", ANL/DIS-09-2, D.F. Brown, H.M. Hartmann, W.A. Freeman, and W.D. Haney, Argonne National Laboratory, Argonne, Illinois, June 2009.

Reactive Group:

Acyl Halides, Sulfonyl Halides, and Chloroformates

Reactivity Alerts:

Highly Flammable

Reactivity Profile:

Acid halides, such as PROPIONYL CHLORIDE, are water reactive; some are violently reactive. They are incompatible with strong oxidizing agents, alcohols, amines, and alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Corrosivity:

Corrosive

See More Propionyl chloride Properties 

Hazard Identification

Classification of the substance or mixture

Flammable liquids, Category 2

Skin corrosion, Sub-category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H225 Highly flammable liquid and vapour H314 Causes severe skin burns and eye damage
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Propionyl chloride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

11 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Wholesale Propanoyl chloride 99.7% kuohuai CAS 79-03-8	1 KG	Sep 27, 2023
Thailand	Propionyl chloride	15 TON	Sep 29, 2023
United States	Propionyl chloride	100 MT	Jul 5, 2025
United States	Propionyl chloride	180 G	Dec 26, 2025
United States	Propionyl chloride	100 G	Mar 19, 2024
India	Propionyl chloride	10.00 KG	Oct 20, 2023
New Zealand	Propionyl chloride	25 L	May 29, 2026
United States	propionyl chloride	1 L	Jan 12, 2026
Mexico	Propionyl chloride	100 KG	Nov 30, 2025
Mexico	Propionyl chloride	100 KG	Nov 29, 2025
United Kingdom	propionyl chloride	1 40' Fcl	May 4, 2025

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