(2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyramide High Purity Isavuconazole Impurity CAS 170863-34-0 NT

(2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyramide (CAS 170863-34-0) is a key chiral intermediate in the synthesis of triazole antifungal agents, including Isavuconazole and Efinaconazole . This compound is also identified as Isavuconazole Impurity 72 and serves as an important reference standard in pharmaceutical quality control .

The molecule features a thioamide functional group, a chiral hydroxyl structure, and a triazole moiety, which are essential building blocks for the biological activity of the final API. Triazole antifungals function as 14α-demethylase inhibitors, effectively blocking ergosterol biosynthesis in fungal cell membranes.

This high-purity intermediate is widely used in pharmaceutical R&D, analytical method development, and quality control applications, including ANDA filing and commercial production of triazole antifungal drugs .

Key Features:

• High Purity: ≥ 98% (HPLC), meeting rigorous quality standards 

• Key Chiral Intermediate: Essential for the synthesis of triazole antifungal APIs

• Impurity Reference Standard: Identified as Isavuconazole Impurity 72 for QC applications 

• Analytical Grade: Suitable for use as a reference standard and impurity identification

• Regulatory Support: Can be provided with detailed characterization data compliant with regulatory guidelines 

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Applications:

• Pharmaceutical Industry: As a key intermediate in the synthesis of Isavuconazole and Efinaconazole APIs

• Analytical R&D: For method development, method validation (AMV), and quality control (QC) applications 

• Regulatory Filing: Used as a reference standard in ANDA and DMF submissions

• Impurity Profiling: As a reference standard for Isavuconazole impurity identification 

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Packaging: ___ (1g, 5g, 10g, 25kg per package, as per customer's request)

Storage: Store in a cool, dry, well-ventilated area, away from direct sunlight and moisture. Recommended storage temperature: 2-8°C (Refrigerator) for long-term storage.

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