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I. Core Basic Mechanism
MT1 is a naturally derived α-MSH artificial modified synthetic peptide, highly selectively binding to the MC1R receptor of skin melanocytes, activating the cAMP signaling pathway, upregulating the MITF melanin regulatory factor, accelerating the synthesis of tyrosinase, and directingly stimulating the production of true melanin. It hardly activates other systemic melanocortin receptors, and the systemic side effects are much less than MT2.
II. Skin Pigmentation and Photoprotection Effects
Promote natural and uniform darkening (without sunburn damage)
Without long-term ultraviolet radiation, it can steadily deepen the skin color, generating dark brown protective true melanin (different from the easily sunburned yellowish red eumelanin); the skin color is evenly colored, and sunspots and uneven color patches are less likely to appear, and the coloring effect can last for several weeks. The skin with a naturally easy-to-sunburn and difficult-to-darken complexion shows the most obvious effect.
Strong ultraviolet protection, reducing sunburn damage
True melanin can absorb UVA/UVB, significantly reducing skin surface burns, redness, and peeling caused by ultraviolet radiation; under the same sun exposure duration, the incidence of skin inflammation and phototoxic pain decreases significantly; it can reduce the ultraviolet-induced epidermal oxidative free radicals and reduce the accumulation of photoaging damage.
Improve photosensitive skin problems
Used in research related to erythropoietic protoporphyria (extremely photosensitive from birth, intense pain upon sun exposure) for alleviating severe sunburn pain through enhancing the skin's melanin barrier; it has potential to alleviate polymorphous light eruption and sun-induced erythema; it assists in the research of re-coloring of leukoplakia and pigment loss scars, and when combined with phototherapy, it can enhance the proliferation activity of melanocytes and improve local pigment loss.
Reduce ultraviolet DNA damage, assist in cell repair
Activate the DNA nucleotide excision repair pathway, accelerate the clearance of damaged DNA fragments caused by ultraviolet radiation, reduce the risk of epidermal cell mutations caused by long-term light exposure; reduce the probability of sun-induced keratosis (pre-cancerous skin lesions from sun exposure), which is one of the core mechanisms of skin anti-photoaging.
III. Anti-inflammatory and Skin Repair Effects (In vitro Cell Experiment Results)
Regulate the secretion of skin inflammatory factors, inhibit chronic low-grade inflammation induced by ultraviolet radiation and external stimuli; alleviate post-sun redness, burning, and persistent redness.
Reduce the level of epidermal oxidative stress, eliminate reactive oxygen species, reduce the oxidation and rupture of collagen and elastic fibers, assist in delaying photoaging wrinkles and relaxation.
Gently repair damaged melanocytes, stabilize the epidermal barrier, reduce the probability of dry itching and peeling after sun exposure in sensitive skin.
IV. Other In vitro Multi-system Research Effects
Neuroprotective effect
In vitro brain tissue cell models, it can reduce the damage of oxidative stress and inflammation to neurons, reduce neuronal apoptosis; used in basic mechanism research related to neurodegenerative damage and cerebral ischemia, assisting in maintaining the survival activity of nerve cells.
Immune regulation effect
Regulate the release of inflammatory mediators of macrophages and keratinocytes, balance the local immune response of the skin; reduce pigment disorders and phototoxic inflammatory reactions caused by excessive immunity.
Organ antioxidant protection
In vitro experiments on liver, kidney, and cardiac muscle cells show that it can enhance the antioxidant capacity of cells, alleviate cell damage and apoptosis caused by chemical and oxidative stimuli, and is mainly used for drug organ toxicity screening research.

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Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.