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I. Local effects of topical application (essence, ointment, wound dressing application)
1. Powerful local analgesia, alleviating various skin pain sensations
Activating the peripheral μ-opioid receptors on the skin surface and blocking the transmission of local pain signals:
Relieving sunburn stinging, abrasion burning pain, mosquito bite itching pain, post-medical treatment wound stinging;
Improving eczema, dermatitis, rosacea-induced persistent burning and itching;
Relieving acne redness and swelling pain, reducing pressure pain, and providing immediate skin discomfort relief.
2. Anti-inflammatory and desaturating, repairing sensitive barrier damage
Inhibiting the release of pro-inflammatory factors TNF-α and IL-6 in the skin, quickly fading redness, burning, and stress red blood vessels;
Promoting the proliferation of keratinocytes, strengthening the tight junction of the keratin layer, improving thin skin, seasonal dryness, and repeated sensitivity of hormone face;
Reducing skin inflammation induced by ultraviolet rays and chemical stimuli, reducing post-inflammatory pigmentation.
3. Accelerating superficial wound and acne repair
Promoting the growth of skin capillaries, accelerating the healing of broken skin, abrasions, and acne damage, shortening the scab formation period;
Enhancing the activity of fibroblasts, promoting collagen formation, reducing superficial scars, uneven acne marks;
Removing apoptotic inflammatory cells from the wound, reducing the probability of post-healing blackening, redness, and mark formation.
4. Anti-aging and tightening, reducing dry lines and fine lines
Stabilizing skin cells and reducing collagen breakdown caused by inflammation; Removing local free radicals, resisting photoaging, improving skin elasticity, and reducing dry fine lines, roughness, and relaxation.
5. Scalp topical auxiliary effect
Relieving scalp itching, folliculitis pain, reducing scalp heat after； Repairing damaged scalp barrier， reducing dandruff， inflammatory hair loss.
II. Systemic conditioning effects (only cyclized modified D3/D4 derivatives， the original Dermorphin oral administration is almost ineffective)
Original straight-chain Dermorphin is extensively decomposed by stomach acid and intestinal peptide enzymes， and is almost impossible to enter the bloodstream to take effect； Only laboratory cyclized modified derivatives have oral bioavailability. The following are the observed effects from animal experiments：
1. Long-term systemic analgesia， alleviating chronic physical pain
Selectively activating central and peripheral μ-receptors， inhibiting the transmission of systemic pain sensation：
Improving muscle soreness after exercise， chronic joint aching， dull pain from labor injuries in the back and waist；
Relieving neuropathic dull pain， migraine， pelvic pain during menstruation；
The analgesic effect lasts for a long time， with the same pain relief intensity， the tolerance and addiction potential is lower than that of morphine-like substances.
2. Soothing the nervous system， calming anxiety， improving stress-induced insomnia
Regulating the endorphin pathway in the central nervous system， reducing cortisol elevated by chronic stress， alleviating restlessness， tension， and somatic anxiety；
Calming overexcited pain nerves， improving sleep difficulty， night pain awakening， and frequent nightmares caused by pain；
Soothing physical tension， alleviating muscle stiffness caused by long-term tension.
3. Bidirectional anti-inflammatory throughout the body， reducing chronic low-grade inflammation
Inhibiting systemic inflammatory factors， improving fatigue， edema， and overall body pain caused by long-term inflammation； Reducing chronic inflammation stimulation of intestinal and respiratory mucosa.
4. Recovery support for athletes
Significantly reducing delayed muscle soreness after high-intensity training， extending the duration of exercise tolerance；
Reducing persistent pain caused by sports injuries， accelerating the repair of minor soft tissue injuries；
Relieving neural hyperexcitability after training， improving the quality of sleep during recovery at night.
5. Mucosal soothing and maintenance (oral cavity， digestive tract)
Sublingual / oral administration can act on the peripheral opioid receptors on the mucosa of the oral cavity and gastrointestinal tract：
Relieving oral ulcers， gum swelling pain， throat dry pain；
Soothing gastrointestinal spasms， abdominal pain， and discomfort caused by irritable bowel syndrome and intestinal hyperactivity.
Hazard Identification
Classification of the substance or mixture
GHS label elements, including precautionary statements
| Pictogram(s) | no data available |
| Signal word | no data available |
| Hazard statement(s) | no data available |
| Precautionary statement(s) |
| Prevention | no data available |
| Response | no data available |
| Storage | no data available |
| Disposal | no data available |
Other hazards which do not result in classification
no data available
Handling and Storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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