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I. Core Mechanism
1. Within the cell, NNMT consumes nicotinamide (NAM) + methyl donor SAM to generate inactive 1-MNA, consuming a large amount of the raw materials for synthesizing NAD⁺, and depleting the cell's methyl reserve SAM;
2. 5-Amino-1MQ occupies the active site of NNMT, blocking this reaction:
- Nicotinamide is no longer wasted and returns to the NMN/NAD⁺ salvage pathway, increasing the cell's NAD⁺ level;
- The SAM methyl pool is retained, maintaining normal methylation and epigenetic regulation of DNA/histones.
3. Unlike direct supplementation of NAD precursors such as NMN and NR: it reduces NAD consumption and retains the cell's energy reserve from the source.
II.
1. Fat loss and improvement of body composition (the most popular effects)
- Inhibiting the generation of fat from scratch in fat cells, reducing the volume of fat cells, and decreasing the accumulation of white fat;
- Enhancing mitochondrial biosynthesis, promoting fatty acid oxidation, and increasing basal energy expenditure;
- Suitable for studies on fat loss and muscle building and shaping, distinct from appetite-suppressing weight loss substances.
2. Improve glucose metabolism and enhance sensitivity
- An increase in NAD⁺ activates SIRT1/SIRT3, enhancing glucose uptake in muscles and liver;
- Lower fasting blood sugar and improve glucose tolerance, effective in models of insulin resistance induced by obesity;
- Reduce liver fat deposition and alleviate lipid disorders associated with non-alcoholic fatty liver disease.
3. Enhance exercise endurance, muscle repair and anti-sarcopenia
- Increase NAD⁺ in skeletal muscles, enhance mitochondrial energy supply, and improve exercise endurance and recovery speed;
- Protect muscle stem cells, reduce exercise injuries, and accelerate muscle repair;
- Alleviate muscle loss caused by aging
4. Anti-aging and Cellular Antioxidation
- Upregulation of NAD⁺ activates longevity proteins Sirtuins (SIRT1/3): repairs DNA, eliminates oxidative free radicals, and reduces chronic inflammation;
- Reduces cellular aging markers and improves metabolic decline associated with aging;
- Stabilizes the methyl cycle, optimizes epigenetic regulation, and delays cellular aging.
5. Neuroprotection and cognitive improvement
- Reduces damage to dopamine neurons in the Parkinson's model, enhances antioxidant effects and reduces brain inflammation;
- Increases brain NAD⁺ levels, improves mitochondrial brain function, and is used for basic research on neurodegenerative diseases.
6. Application of Anti-Tumor Microenvironment Research
Tumor stromal cells highly express NNMT, which consumes NAD⁺ to create a microenvironment conducive to tumor growth;

Hong Kong Biopetide Research Limited is a high-tech enterprise specializing in the research, development, production, and sales of peptide products. The company boasts advanced laboratories and a rigorous quality control system, with its products having obtained multiple international certifications, ensuring safety and efficacy.
Its customers are spread across Europe, the United States, Southeast Asia, the Middle East, and other regions.
Biotechnology Co., Ltd. is a high-tech enterprise specializing in the research, development, production, and sales of peptide products. With advanced laboratories and a rigorous quality control system, our products have obtained international certification, ensuring safety and efficacy.
As a global trading company, we provide customized solutions to customers across Europe, the United States, Southeast Asia, the Middle East, and many other regions. Upholding the philosophy of "technology leading health," we are committed to innovation, striving to deliver high-quality health products to consumers worldwide. Our business principles focus on establishing a strong domestic market presence, increasing R&D investment, manufacturing premium products, and leveraging technology to promote environmental protection and sustainable development. At the same time, we actively expand into international markets, serve society with sincerity, and aim to become a modern, eco-friendly, and technologically advanced enterprise that meets global standards. Contact Us

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