2-(Pyrimidin-5-yl)benzaldehyde

The microwave vials (20 ml) were charged with 2-formylphenylboronic acid (290 mg, 2.0 mmol), 5-bromo-pyrimidine (316 mg, 2.0 mmol) and 8 ml of acetonitrile. To the mixture was added 4 ml of an aqueous solution of sodium carbonate (1 M), followed by the addition of 100 mg of dichlorobis (triphenylYlphosphine) -palladium (II). The reaction vessel was sealed and heated at 150 & lt; 0 & gt; C for 5 minutes with microwave irradiation. After cooling the reaction mixtureExtracted with ethyl acetate. The organic layer was evaporated to provide a crude material which was purified by ISCO to give 220 mg of 2-pyrimidin-5-yl-benzaldehyde.

Molecular Weight:184.19
XLogP3:1.3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:184.063662883
Monoisotopic Mass:184.063662883
Topological Polar Surface Area:42.8
Heavy Atom Count:14
Complexity:190
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes