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Beclobrate

Beclobrate structure

CAS No:
55937-99-0
Formula:
C20H23ClO3
Chemical Name:
Beclobrate
Synonyms:
Butanoic acid,2-[4-[(4-chlorophenyl)methyl]phenoxy]-2-methyl-,ethyl ester;Butanoic acid,2-[4-[(4-chlorophenyl)methyl]phenoxy]-2-methyl-,ethyl ester,(±)-;Beclobrate;Beclipur;Turec;Sgd 24774;57081-61-5
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

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Description

Beclobrate is a diarylmethane.

Beclobrate Basic Attributes

Molecular Weight：

346.852

Exact Mass：

346.85

EC Number：

259-912-4

HScode：

2918990090

Characteristics

PSA：

35.5

XLogP3：

5.04140

Density：

1.128g/cm3

Boiling Point：

200-204 °C @ Press: 0.01-0.1 Torr

Flash Point：

149.6ºC

Refractive Index：

1.541

Toxicity：

LD50 orally in mice: 8000 mg/kg (Thiele, 1979)

Drug Information

MeSH：

Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. (See all compounds classified as Hypolipidemic Agents.)

MeSH Entry Terms：

2-(4-((4-chlorophenyl)methyl)phenoxy)-2-methylbutanoic acid ethyl ester

Beclobrate Use and Manufacturing

Hypolipidemic drugs. It can reduce the excessively high cholesterol and triglyceride in the blood, reduce the VLDL and LDL, increase the HDL, and prevent platelet aggregation. It can be used in patients with hyperlipidemia who are treated with various types of acceptable drugs and the effect of single diet therapy is not obvious. It can also be used for primary diseases including diabetes, thyroid disease, pancreatitis, renal insufficiency, liver cirrhosis or the use of glucocorticoids , Patients with uncontrolled blood lipids caused by ovulation inhibitors or diuretics.

Computed Properties

Molecular Weight:346.8
XLogP3:5.8
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:346.1335723
Monoisotopic Mass:346.1335723
Topological Polar Surface Area:35.5
Heavy Atom Count:24
Complexity:384
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Magnesium sulfate heptahydrate

Hexane

Xylene

Sodium bicarbonate

Potassium carbonate

Ethanol

Potassium bromide

Methyl ethyl ketone