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Home > Encyclopedia > Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)-, (2Z)-2-butenedioate (1:1)

Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)-, (2Z)-2-butenedioate (1:1)

Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)-, (2Z)-2-butenedioate (1:1) structure

Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)-, (2Z)-2-butenedioate (1:1) 

structure
  • CAS No:

    64006-44-6

  • Formula:

    C19H20FNO3.C4H4O4

  • Chemical Name:

    Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)-, (2Z)-2-butenedioate (1:1)

  • Synonyms:

    Piperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-,(3S,4R)-,(2Z)-2-butenedioate (1:1);Piperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-,(3S-trans)-,(Z)-2-butenedioate;FG 7051 maleate;Paroxetine maleate;Paroxetine maleate (1:1);217797-12-1

  • Categories:

    Analytical Chemistry  >  Standard

Description

ChEBI: A maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibi ion of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2

Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)-, (2Z)-2-butenedioate (1:1) Basic Attributes

445.44

445.15400

200-659-6

Characteristics

114.32000

3.36710

white solid

1.213 g/cm3

136-138°C

451.7ºC at 760 mmHg

9℃

DMSO: ~12 mg/mL

Store at RT

LD50 in mice (mg/kg): 845 s.c.; 500 orally (Christensen, Squires, 1977)

D -87° (c = 5 in ethanol)

Safety Information

III

6.1(b)

3249

3

22-36/37/38-39/23/24/25-23/24/25-11

26-36-45-36/37-16-7

TM4569300

Xn,T,F

P261-P305 + P351 + P338

H302-H315-H319-H335

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