 Home > Encyclopedia > Oxazolone

Oxazolone

Oxazolone structure

CAS No:
15646-46-5
Formula:
C12H11NO3
Chemical Name:
Oxazolone
Synonyms:
5(4H)-Oxazolone,4-(ethoxymethylene)-2-phenyl-;2-Oxazolin-5-one,4-(ethoxymethylene)-2-phenyl-;4-(Ethoxymethylene)-2-phenyl-5(4H)-oxazolone;2-Phenyl-1-4-heteromethylene-5-oxazolone;Oxazolone;2-Phenyl-4-ethoxymethylene-5-oxazolone;2-Phenyl-4-(ethoxymethylene)oxazolone;Oxazolone (sensitizing agent);2-Phenyl-4-(ethoxymethylene)-2-oxazolinone;4-Ethoxymethylene-2-phenyl oxazolone;4-Ethoxymethylene-2-phenyl-5-oxazolone;Oxazolone (allergen);4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one
Categories:
Analytical Chemistry > Standard

Description

white to orange or pink powderChEBI: A 1,3-oxazole compound having a phenyl substituent at the 2-position, an ethoxymethylene group at the 4-position, and an oxo group at the 5-position. It is a chemical allergen used for immunological experiments, particularly for experiments on delayed typ hypersensitivity.

4-(ethoxymethylene)-2-phenyloxazol-5-one is a 1,3-oxazole compound having a phenyl substituent at the 2-position, an ethoxymethylene group at the 4-position, and an oxo group at the 5-position. It is a chemical allergen used for immunological experiments, particularly for experiments on delayed type hypersensitivity. It has a role as an allergen. It is a member of 1,3-oxazoles and a gamma-lactone.|Immunologic adjuvant and sensitizing agent.

Oxazolone Basic Attributes

Molecular Weight：

217.22

Exact Mass：

217.22

BRN：

163055

EC Number：

239-713-9

UNII：

40RAK33386

DSSTox ID：

DTXSID1049225

HScode：

29349990

Characteristics

PSA：

47.89000

XLogP3：

1.30350

Density：

1.2160 (rough estimate)

Melting Point：

94-96 °C

Boiling Point：

357.77°C (rough estimate)

Flash Point：

136.8ºC

Refractive Index：

1.5560 (estimate)

Water Solubility：

Soluble in methanol (50 mg/ml), and water (partly).

Storage Conditions：

2-8°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

RQ5786250

Marks：

Precautionary statement(s)：

P280

Hazard Statements：

H317

GHS Classification：

|Warning|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P302+P352, P321, P333+P313, P363, and P501|Aggregated GHS information provided by 42 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)

MeSH Entry Terms：

2-Phenyl-4-(ethoxymethylene)oxazol-5-one

Computed Properties

Molecular Weight:217.22
XLogP3:2.1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:217.07389321
Monoisotopic Mass:217.07389321
Topological Polar Surface Area:47.9
Heavy Atom Count:16
Complexity:327
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Oxazolone

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE

CAS No.: 15646-46-5

Content: 99.00%

Inquiry