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Minaprine

Minaprine structure

CAS No:
25905-77-5
Formula:
C17H22N4O
Chemical Name:
Minaprine
Synonyms:
4-Morpholineethanamine,N-(4-methyl-6-phenyl-3-pyridazinyl)-;N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine;Minaprine;Mineprine
Categories:
Analytical Chemistry > Standard

Description

Minaprine is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.

Solid

Minaprine is a member of pyridazines, a secondary amine and a member of morpholines. It has a role as an antidepressant, a serotonin uptake inhibitor, a dopamine uptake inhibitor, a cholinergic drug and an antiparkinson drug.|Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.

Minaprine Basic Attributes

Molecular Weight：

371.3

Exact Mass：

298.38

EC Number：

247-329-8

UNII：

00U7GX0NLM

DSSTox ID：

DTXSID5048477

ATC Code：

N - Nervous system

HScode：

2934999090

Characteristics

PSA：

50.28000

XLogP3：

3.81100

Density：

1.156g/cm3

Melting Point：

122 °C

Boiling Point：

531.2ºC at 760 mmHg

Flash Point：

275.1ºC

Refractive Index：

1.595

Water Solubility：

7.01e-02 g/L

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

QE3477830

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

Drug Indication：

For the treatment of depression

Pharmacology：

Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain. Similar to other antidepressant treatments, minaprine attenuates the beta-adrenergic receptor function. Studies have also shown that minaprine improves memory consolidation and that repeated drug administration leads to potentiation of this effect. Moreover, the effects of minaprine on memory consolidation are related to its dopaminergic action.

MeSH：

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)

Metabolism/Metabolites：

Hepatic. Cytochrome P4502D is responsible for the 4-hydroxylation of minaprine to 4-hydroxyminaprine.|Minaprine has known human metabolites that include 4-Hydroxyminaprine.

Mechanism of Action：

Minaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree, cholinomimetic. Thus it may exhibit both mood-brightening and nootropic properties. It also acts as a reversible inhibitor of MAO-A (RIMA).It has also been found to inhibit acetylcholinesterase.

MeSH Entry Terms：

3-(2-morpholino-ethylamino)-4-methyl-6-phenyl pyridazine, dihydrochloride

Minaprine Use and Manufacturing

muscle relaxant (skeletal)

Computed Properties

Molecular Weight:298.4
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:298.17936134
Monoisotopic Mass:298.17936134
Topological Polar Surface Area:50.3
Heavy Atom Count:22
Complexity:316
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes