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Citreoviridin

Citreoviridin structure

CAS No:
25425-12-1
Formula:
C23H30O6
Chemical Name:
Citreoviridin
Synonyms:
D-Iditol,2,5-anhydro-1,6-dideoxy-2-C-[(1E,3E,5E,7E)-8-(4-methoxy-5-methyl-2-oxo-2H-pyran-6-yl)-2-methyl-1,3,5,7-octatetraen-1-yl]-4-C-methyl-;2H-Pyran-2-one,4-methoxy-5-methyl-6-[7-methyl-8-(tetrahydro-3,4-dihydroxy-2,4,5-trimethyl-2-furyl)-1,3,5,7-octatetraenyl]-;2H-Pyran-2-one,4-methoxy-5-methyl-6-[7-methyl-8-(tetrahydro-3,4-dihydroxy-2,4,5-trimethyl-2-furanyl)-1,3,5,7-octatetraenyl]-,[2S-[2α(1E,3E,5E,7E),3β,4α,5α]]-;2,4,6,8,10,12-Tridecahexaenoic acid,5-hydroxy-3-methoxy-4,12-dimethyl-13-(tetrahydro-3,4-dihydroxy-2,4,5-trimethyl-2-furyl)-,δ-lactone;D-Iditol,2,5-anhydro-1,6-dideoxy-2-C-[(1E,3E,5E,7E)-8-(4-methoxy-5-methyl-2-oxo-2H-pyran-6-yl)-2-methyl-1,3,5,7-octatetraenyl]-4-C-methyl-;2,5-Anhydro-1,6-dideoxy-2-C-[(1E,3E,5E,7E)-8-(4-methoxy-5-methyl-2-oxo-2H-pyran-6-yl)-2-methyl-1,3,5,7-octatetraen-1-yl]-4-C-methyl-D-iditol;Citreoviridin A;Citreoviridine A;Citreoviridin;Citreoviridine
Categories:
Analytical Chemistry > Standard

Description

Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na+/K+-ATPase whereas in microsomes, both Na+/K+-ATPase and Mg2+-ATPase activities are significantly stimulated in a dose-dependent manner[1]. Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells[2].

Citreoviridin Basic Attributes

Molecular Weight：

402.484

Exact Mass：

402.48

HScode：

29322090

Characteristics

PSA：

89.13000

XLogP3：

3.04

Density：

1.2±0.1 g/cm3

Melting Point：

107-111 °C

Boiling Point：

585.1±50.0 °C at 760 mmHg

Flash Point：

197.7±23.6 °C

Refractive Index：

1.569

Storage Conditions：

2-8°C

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

3172

hazard class code：

63-23/24/25-36/37/38

safety instructions：

22-26-36/37/39-45

RTECS Number：

UQ1235000

Marks：

Precautionary statement(s)：

P261-P264-P280-P301 + P310-P305 + P351 + P338-P311

Hazard Statements：

H300-H311-H315-H319-H331-H335-H361

Citreoviridin Use and Manufacturing

Citreoviridin is a mycotoxin isolated from several Penicillium species that has been shown to inhibit the mitochondrial ATP synthetase system. It inhibits soluble ATPase (KD = 4.1 μM), ADP-stimulated respiration in isolated rat liver mitochondria (KD = 0.15 μM), and ATP-driven reduction of NAD+ by succinate (KD = 2 μM). Citreoviridin has been used to target ectopic ATPase activity in cancer cells in order to modulate the metabolic activity associated with tumorigenesis.[Cayman Chemical]