Pachymic acid
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Pachymic acid
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CAS No:
29070-92-6
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Formula:
C33H52O5
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Chemical Name:
Pachymic acid
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Synonyms:
Lanost-8-en-21-oic acid,3-(acetyloxy)-16-hydroxy-24-methylene-,(3β,16α)-;Lanost-8-en-21-oic acid,3β,16α-dihydroxy-24-methylene-,3-acetate;Eburica-8,24(28)-dien-21-oic acid,3β,16α-dihydroxy-,3-acetate;(3β,16α)-3-(Acetyloxy)-16-hydroxy-24-methylenelanost-8-en-21-oic acid;Pachymic acid;3-O-Acetyltumulosic acid;NSC 244427
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CAS No:
Description
Pachymic acid is a lanostrane-type triterpenoid from P. cocos. Pachymic acid inhibits Akt and ERK signaling pathways.
Characteristics
83.8
8.59
White Powder
1.1±0.1 g/cm3
300 °C @ Solvent: Methanol, Acetone
612.2±55.0 °C at 760 mmHg
184.7±25.0 °C
1.540
1.51E-17mmHg at 25°C
Pachymic acid Use and Manufacturing
Pachymic acid (PA) is a natural triterpenoid known to inhibit the phospholipase A2 (PLA(2)) family of arachidonic acid (AA)-producing enzymes, PA-treatment decreases bad phosphorylation, increases Bcl-2 phosphorylation, and activates caspases-9 and -3, it also decreases the expression and activation of proteins within the AKT signal pathway. suggests that PA initiates apoptosis through mitochondria dysfunction and influences apoptosis by reducing prostaglandin.
Pachymic acid can exhibit antiinflammatory and anticancer properties, it can inhibit cell growth and modulate arachidonic acid metabolism in nonsmall cell lung cancer A549 cells by its inhibition of MAPKs and NF-kappaB signaling pathways; it can impair breast cancer cell invasion by suppressing nuclear factor-κB-dependent matrix metalloproteinase-9 expression.
Pachymic acid has antioxidant activity, affects the removal effect of reactive oxygen species formation as did N-acetyl-L-cysteine and inhibits nuclear factor-κB translocation, it can mitigate the unfavorable conditions induced by AH Plus stimuli, therefore, the use of pachymic acid is suggested to prevent the complications of oral diseases such as inflammation and alveolar destruction of the oral cavity.
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