Reactive Blue 4

Reactive Blue 4 is an anthraquinone dye, as a single colorimetric chemosensor for sequential determination of multiple analytes with different optical responses in aqueous media. Reactive Blue 4 is phytotoxic, cytotoxic and genotoxic. Reactive Blue 4 [1][2].

Taking bromamine acid, 2, 4-diaminobenzene sulfonic acid, and cyanuric acid as raw materials, firstly condense 2, 4-diaminobenzene sulfonic acid and bromamine acid, and then further condense with cyanuric acid. Subcondensation, salting out, filtering and drying to obtain finished products. . . Add 500L of clear water to the first condensation pot, and heat to 85°C while stirring. Add 191kg bromamine acid (100%), and stir to form a uniform suspension (total volume about 1000L). Then add 112.8kg 2, 4-diaminobenzenesulfonic acid (100%), 200kg sodium bicarbonate (100%), heat to 85°C, keep for 30min, add 10kg cuprous chloride (100%) solution (without free Sulfite). Control at 83-85℃, pH=9 and react for 3h. Measure the end point (the sampling is spread out on filter paper, and the end point is the disappearance of bromamine). Keep holding at 90°C for 2h. At the end of the reaction, add water to dilute to 4500L, stir for 15min, add 150kg of light calcium carbonate, stir at 75-80℃ for 30min, filter while hot to remove the purple by-product dye. Put the filtrate into the neutralization pot, adjust the pH to 2 with hydrochloric acid, add 10%-15% salt of the solution volume, stir for 1h, take a sample to measure the end point (the end point is no blue percolation circle on the filter paper), and filter to get Refined filter cake. Add 1000L of water to the dissolving pot, add 30kg of sodium carbonate and refined filter cake under stirring, beating, adjust the volume to 3000L, pH=7.5, and obtain a refined liquid. Add 300L of water to the second condensation pot, add 81.1kg (about 0.44kmol) of cyanuric chloride, beat for 45min below 0°C, add the refined liquid prepared in the previous step, adjust the volume to 4500L at 15°C, stir for 1h, Add trisodium phosphate so that the pH is about 6.5; continue stirring for 3 hours, the pH value should be maintained between 6.3-6.5, and the temperature should not exceed 18°C. Filter to remove cyanuric chloride impurities. The filtrate was collected in the salting-out pot, 26.4kg (about 0.44kmol) of urea was added to the filtrate, the temperature was raised to 43℃ within 1h, and 20% salt of the total volume of the filtrate was added, stirred at 40-42℃ for 2h, and sampled (on the filter paper) It is enough if the spots are clear), filter, and dry the filter cake at 80-85°C to obtain about 410kg of dye.

Used for dyeing and printing cotton, silk, viscose and other fabrics

Molecular Weight:637.4
XLogP3:4.7
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:6
Exact Mass:635.9691592
Monoisotopic Mass:635.9691592
Topological Polar Surface Area:248
Heavy Atom Count:41
Complexity:1220
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes