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LY310762

LY310762 structure

CAS No:
192927-92-7
Formula:
C24H27O2N2FHCl
Chemical Name:
LY310762
Synonyms:
LY-310,762 HYDROCHLORIDE;3,3-Dimethyl-1-{2-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-ethyl}-1,3-dihydro-2H-indol-2-onehydrochloride;1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-onehydrochloride;LY 310762 HCl;1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-diMethylindolin-2-one Hydrochloride;2H-Indol-2-one, 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-diMethyl-, Monohydrochloride
Categories:
Biochemical Engineering > Inhibitors

Description

LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.IC50 value: 249 nM (Ki) [1]Target: 5-HT1D in vitro: LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 of 30 nM. The maximum potentiation of the potassium-induced outflow which is obtained with LY310762 is about 40% [1]. LY310762 blocks

LY-310762 hydrochloride is a hydrochloride resulting from the formal reation of equimolar amount of LY-310762 with hydrogen chloride. A potent and selective antagonist for the 5-hydroxytryptamine 1D (5-HT1D) receptor. It has a role as a receptor modulator and a serotonergic antagonist. It contains a LY-310762(1+).

LY310762 Basic Attributes

Molecular Weight：

430.948

Exact Mass：

430.18200

DSSTox ID：

DTXSID80474689

Characteristics

PSA：

40.6

XLogP3：

4.84970

Appearance：

white powder

Water Solubility：

DMSO: 10 mg/mL with heating, soluble

Storage Conditions：

Desiccate at RT

Safety Information

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Drug Information

MeSH Entry Terms：

1-(2-(4-(4-fluoro-benzoyl)-piperidin-1-yl)-ethyl)-3,3-dimethyl-1,2-dihydro-indol-2-one

LY310762 Use and Manufacturing

5-HT 1D -preferring receptor antagonist (EC 50 = 31 nM). Displays no activity on 5-HT transport.

Computed Properties

Molecular Weight:430.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:430.1823340
Monoisotopic Mass:430.1823340
Topological Polar Surface Area:40.6
Heavy Atom Count:30
Complexity:606
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes