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Ciproxifan

Ciproxifan structure

CAS No:
184025-18-1
Formula:
C16H18N2O2
Chemical Name:
Ciproxifan
Synonyms:
Methanone,cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]-;Methanone,cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxy]phenyl]-;Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone;Ciproxifan;FUB 359
Categories:
Biochemical Engineering > Inhibitors

Description

Ciproxifan(FUB-359) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.IC50 value: 9.2 nM(Ki)Target: H3 receptorIn vitro, Ciproxifan behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor

Cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone is an aromatic ketone.

Ciproxifan Basic Attributes

Molecular Weight：

386.4

Exact Mass：

270.33

UNII：

5EVQ7IRG99

DSSTox ID：

DTXSID50171532

Characteristics

PSA：

XLogP3：

2.29

Appearance：

white solid

Density：

1.231

Boiling Point：

526.9±35.0 °C(Predicted)

Flash Point：

272.5±25.9 °C

Refractive Index：

1.613

Water Solubility：

H2O: insoluble

Safety Information

wgk germany：

hazard class code：

22-36/37/38-43

safety instructions：

26-36/37/39

Marks：

Drug Information

MeSH：

Drugs that selectively bind to but do not activate HISTAMINE H3 RECEPTORS. They have been used to correct SLEEP WAKE DISORDERS and MEMORY DISORDERS. (See all compounds classified as Histamine H3 Antagonists.)

MeSH Entry Terms：

ciproxifan

Computed Properties

Molecular Weight:270.33
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:270.136827821
Monoisotopic Mass:270.136827821
Topological Polar Surface Area:55
Heavy Atom Count:20
Complexity:322
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes