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1-AZAKENPAULLONE

1-AZAKENPAULLONE structure

CAS No:
676596-65-9
Formula:
C15H10BrN3O
Chemical Name:
1-AZAKENPAULLONE
Synonyms:
1-AZAKENPAULLONE;9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one;Pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one, 9-broMo-7,12-dihydro-;1-Azakenpaullone 9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one;InSolution? 1-Azakenpaullone
Categories:
Biochemical Engineering > Inhibitors

Description

1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β), with an IC50 value of 18 nM[1].

1-azakenpaullone is an organic heterotetracyclic compound that is 7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indole substituted at positions 6 and 9 by oxo and bromo groups respectively. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor and a Wnt signalling activator. It is an organic heterotetracyclic compound, an organonitrogen heterocyclic compound, a lactam and an organobromine compound.

1-AZAKENPAULLONE Basic Attributes

Molecular Weight：

328.169

Exact Mass：

327.000702

DSSTox ID：

DTXSID8042686

Characteristics

PSA：

57.78000

XLogP3：

3.19

Appearance：

gray-brown

Density：

1.7±0.1 g/cm3

Melting Point：

>290°C (dec.)

Boiling Point：

648.8±50.0 °C at 760 mmHg

Flash Point：

346.2±30.1 °C

Refractive Index：

1.740

Water Solubility：

DMSO: >10mg/mL

Storage Conditions：

-20°C Freezer

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH Entry Terms：

1-azakenpaullone

1-AZAKENPAULLONE Use and Manufacturing

A selective inhibitor of glycogen synthase kinase-3β.

Computed Properties

Molecular Weight:328.16
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:327.00072
Monoisotopic Mass:327.00072
Topological Polar Surface Area:57.8
Heavy Atom Count:20
Complexity:405
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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1-Azakenpaullone 99% see COA Kanbei kanbei

CAS No.: 676596-65-9

Grade: Industrial Grade

Content: 99%

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