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Dalcetrapib

Dalcetrapib structure

CAS No:
211513-37-0
Formula:
C23H35NO2S
Chemical Name:
Dalcetrapib
Synonyms:
Propanethioic acid,2-methyl-,S-[2-[[[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino]phenyl] ester;JTT 705;Dalcetrapib
Categories:
Biochemical Engineering > Inhibitors

Description

Dalcetrapib (JTT-705; RO-4607381) is a rhCETP inhibitor with IC50 of 0.2 μM that increases the plasma HDL cholesterol. IC50 value: 0.2 uM [1]Target: CETPin vitro: Dalcetrapib modulates CETP activity. Dalcetrapib induces a conformational change in CETP, when added to human plasma. CETP-induced pre-β-HDL formation in human plasma is unchanged by Dalcetrapib ≤3 μM and increased at 10 μM. Dalcetrapib statistically and significantly increases pre-β-HDL formation [1]. Dalcetrapib achieves 50%

Dalcetrapib Basic Attributes

Molecular Weight：

389.59

Exact Mass：

389.59

Characteristics

PSA：

71.5

XLogP3：

7.1

Density：

1.066 g/cm3

Melting Point：

63-63.5 °C

Flash Point：

273.676ºC

Safety Information

Precautionary statement(s)：

P273, P501

Hazard Statements：

H413

Dalcetrapib Use and Manufacturing

Dalcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor. Dalcetrapib is a drug undergoing trials for the treatment of cardiovascular disease, dyslipidemia, peripheral arterial disease (PAD).

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