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GNE 7915

GNE 7915 structure

CAS No:
1351761-44-8
Formula:
C19H21F4N5O3
Chemical Name:
GNE 7915
Synonyms:
GNE 7915;[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone;GNE-7915, >=98%;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol
Categories:
Biochemical Engineering > Inhibitors

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GNE 7915 Basic Attributes

Molecular Weight：

443.3953528

Exact Mass：

443.158

Characteristics

PSA：

88.6

XLogP3：

2.8

Density：

1.404±0.06 g/cm3(Predicted)

Boiling Point：

629.9±65.0 °C(Predicted)

Drug Information

MeSH Entry Terms：

(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone

GNE 7915 Use and Manufacturing

Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity.GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]

Computed Properties

Molecular Weight:443.4
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:6
Exact Mass:443.15805220
Monoisotopic Mass:443.15805220
Topological Polar Surface Area:88.6
Heavy Atom Count:31
Complexity:593
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes