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vexibinol

vexibinol structure

CAS No:
97938-30-2
Formula:
C25H28O6
Chemical Name:
vexibinol
Synonyms:
vexibinol;(S)-2,3-Dihydro-5,7-dihydroxy-2-(2,4-dihydroxyphenyl)-6-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one;(2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2,4-dihydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one,2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-,(2S)-;Sophoraavanone G;(2S)-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-[(2S)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one;Sophoraflavanone G,Inhibitor,anti-infammatory,HL60,inhibit,Apoptosis;Hybutimibe Impurity 23
Categories:
Natural Products > Flavonoids

Description

Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties. Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways[1][2].

Sophoraflavanone G is a tetrahydroxyflavanone having a structure of naringenin bearing an additional hydroxyl substituent at position 2' as well as a (2R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl (lavandulyl) substituent at position 8'. It has a role as an antioxidant, an antimalarial, an antimicrobial agent and a plant metabolite. It is a tetrahydroxyflavanone, a member of 4'-hydroxyflavanones and a (2S)-flavan-4-one. It derives from a (S)-naringenin.

Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

vexibinol Basic Attributes

Molecular Weight：

424.49

Exact Mass：

424.49

DSSTox ID：

DTXSID10243345

Color/Form：

White-yellowish

Characteristics

PSA：

107

XLogP3：

6.52

Density：

1.266±0.06 g/cm

Melting Point：

173-175℃

Boiling Point：

659.3±55.0 °C(Predicted)

Flash Point：

224.8±25.0 °C

Refractive Index：

1.623

Water Solubility：

sparingly soluble in water

PKA：

7.66±0.40(Predicted)

Critical Temperature & Pressure：

Store at -20°C

Safety Information

wgk germany：

WGK 3

Drug Information

MeSH Entry Terms：

5,7,2',4'-tetrahydroxy-8-lavandulyl-flavanone

vexibinol Use and Manufacturing

Sophoraflavanone G is a flavonoids of Sophora flavescens Ait. which exhibits antibacterial activity. Also, it is reported to exhibits anti-inflammatory activity.

Computed Properties

Molecular Weight:424.5
XLogP3:5.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:424.18858861
Monoisotopic Mass:424.18858861
Topological Polar Surface Area:107
Heavy Atom Count:31
Complexity:684
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Kushenol F

CAS No.: 97938-30-2

Content: 99.00%

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Guide of vexibinol

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
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