Bismerthiazol

Preparation of dithiourea in the dithiourea route Put 180kg of hydrazine sulfate, a small amount of catalyst, and 165kg of ammonium thiocyanate into the reactor, heat to reflux, cool, filter, wash with water, and filter to obtain dithiourea. Preparation of 2-amino-5-mercapto-1, 3, 4-thiadiazole Put 350kg of hydrochloric acid and a small amount of catalyst into the synthesis kettle, then add an appropriate amount of solvent, and then put in the previous reaction product dithiourea under stirring, and heat up To 105° C., reflux and react for a period of time, stir and cool, filter and wash, and suction to dryness to obtain 2-amino-5-mercapto-1, 3, 4-thiadiazole. Synthesis of Ecumazole After stirring and dissolving 150 kg of 2-amino-5-mercapto-1, 3, 4-thiadiazole, the calculated amount of formaldehyde solution was added dropwise, the reaction was stirred, and hydrochloric acid was added dropwise to adjust the pH to less than 1. The material is discharged and centrifuged under stirring, washed with water, and dried to obtain the original powder of eclozole. For the thiosemicarbazide route, add 180g (85%) of hydrazine hydrate into the reaction flask, add a certain concentration of dilute sulfuric acid dropwise under cooling, stir and react for 10-15 minutes at a pH of 4 to 4.5 below 40°C, and then add 96% thiocyanate 85g ammonium acid, the temperature drops automatically, and it is heated in a water bath. When the temperature rises to 112～114℃, reflux reaction. After the reaction, the reactants are poured into a beaker while hot, and the reaction flask is washed with a small amount of hot water. The washing liquid is incorporated into the reactants and left to cool to precipitate yellow crystals. Filter and cool water. Wash and dry to get thiosemicarbazide. Preparation of 2-amino-5-mercapto-1, 3, 4-thiadiazole Add a certain amount of reaction medium and 42 mL of carbon disulfide to the reaction product of the previous step, stir, heat in a water bath, and react under reflux. After the reaction, the solvent was removed under reduced pressure, and water was added to continue distillation to take away the residual solvent, which was used for the synthesis of ecumazole after post-treatment. The process of synthesizing leaf cumazole is the same as that of thiourea route 3.

It is a high-efficiency, low-toxic and low-residue fungicide, used to control bacterial blight in early, middle and late rice seedling fields and Honda

Molecular Weight:278.4
XLogP3:1.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:277.95367891
Monoisotopic Mass:277.95367891
Topological Polar Surface Area:188
Heavy Atom Count:15
Complexity:329
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes