Benzoic acid, 2-(chlorosulfonyl)-, methyl ester

white to beige or pink crystalline powder

It is derived from methyl anthranilate through diazotization, replacement and chlorination. After the methyl anthranilate and sodium nitrite solution are mixed uniformly, they are added dropwise to a mixture of sulfuric acid and hydrochloric acid at about 10°C, and the temperature is controlled not to exceed 25°C. The reaction is stirred until the potassium iodide starch solution is light purple. This diazonium liquid was cooled to 10°C, copper sulfate was added, and sulfur dioxide was introduced after all dissolution. The temperature was about 24°C, and methyl o-sulfinic acid benzoate was precipitated for about 1 hour. After 3h, the replacement end point should be colorless when tested with H acid test paper. Add toluene, and pass chlorine to the end point at 30-35°C (2% benzidine ethanol test solution test shows dark green). Set aside and separate the organic layer to obtain a toluene solution of methyl o-sulfonyl chloride benzoate, which is the finished product after desolvation.

This product is an intermediate of saccharin sodium.

Molecular Weight:234.66
XLogP3:1.8
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:233.9753576
Monoisotopic Mass:233.9753576
Topological Polar Surface Area:68.8
Heavy Atom Count:14
Complexity:306
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes