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(-)-Ketorolac

(-)-Ketorolac structure

CAS No:
66635-92-5
Formula:
C15H13NO3
Chemical Name:
(-)-Ketorolac
Synonyms:
1H-Pyrrolizine-1-carboxylic acid,5-benzoyl-2,3-dihydro-,(1S)-;1H-Pyrrolizine-1-carboxylic acid,5-benzoyl-2,3-dihydro-,(S)-;(1S)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;S-(-)-Ketorolac;(S)-Ketorolac;(-)-Ketorolac
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

(S)-Ketorolac is a nonsteroidal anti-inflammatory agent. (S)-ketorolac exhibits potent COX1 and COX2 enzyme inhibition[1].

(S)-ketorolac is a 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has S configuration. While (S)-ketorolac is a COX1 and COX2 inhibitor, both enantiomers exhibit analgesic effects. Racemic ketorolac, known simply as ketorolac, is used (mainly as the tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It has a role as an analgesic, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor and a non-steroidal anti-inflammatory drug. It is an enantiomer of a (R)-ketorolac.

(-)-Ketorolac Basic Attributes

Molecular Weight：

255.273

Exact Mass：

255.27

Characteristics

PSA：

59.3

XLogP3：

2.08

Density：

1.3±0.1 g/cm3

Melting Point：

>250 °C

Boiling Point：

493.2±40.0 °C at 760 mmHg

Flash Point：

252.1±27.3 °C

Refractive Index：

1.659

Storage Conditions：

Refrigerator

(-)-Ketorolac Use and Manufacturing

The R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.

Computed Properties

Molecular Weight:255.27
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:255.08954328
Monoisotopic Mass:255.08954328
Topological Polar Surface Area:59.3
Heavy Atom Count:19
Complexity:376
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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(S)-Ketorolac 99% white powder GB0266 Greenbo

CAS No.: 66635-92-5

Grade: Pharmaceutical Grade

Content: 99%

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