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(+)-Ketorolac

(+)-Ketorolac structure

CAS No:
66635-93-6
Formula:
C15H13NO3
Chemical Name:
(+)-Ketorolac
Synonyms:
1H-Pyrrolizine-1-carboxylic acid,5-benzoyl-2,3-dihydro-,(1R)-;1H-Pyrrolizine-1-carboxylic acid,5-benzoyl-2,3-dihydro-,(R)-;(1R)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;R-(+)-Ketorolac;(R)-Ketorolac;(+)-Ketorolac
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

(R)-Ketorolac is the R-enantiomer of Ketorolac, shows potent analgesic activity, reduces ulcerogenic potential. (R)-Ketorolac is inactive on COX[1].

(R)-ketorolac is a 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has R configuration. Unlike the S-enantiomer, it does not exhibit COX1 and COX2 inhibition, but does exhibit analgesic activity. Racemic ketorolac, known simply as ketorolac, is used (mainly as a tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It has a role as an analgesic. It is an enantiomer of a (S)-ketorolac.

(+)-Ketorolac Basic Attributes

Molecular Weight：

255.273

Exact Mass：

255.27

Characteristics

PSA：

59.3

XLogP3：

2.08

Density：

1.3±0.1 g/cm3

Melting Point：

174 °C

Boiling Point：

493.2±40.0 °C at 760 mmHg

Flash Point：

252.1±27.3 °C

Refractive Index：

1.659

Storage Conditions：

Refrigerator

(+)-Ketorolac Use and Manufacturing

(R)-Ketorolac is the R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.

Computed Properties

Molecular Weight:255.27
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:255.08954328
Monoisotopic Mass:255.08954328
Topological Polar Surface Area:59.3
Heavy Atom Count:19
Complexity:376
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes