2-Chloro-3-amino-5-bromopyridine
-
2-Chloro-3-amino-5-bromopyridine
structure -
-
CAS No:
588729-99-1
-
Formula:
C5H4BrClN2
-
Chemical Name:
2-Chloro-3-amino-5-bromopyridine
-
Synonyms:
5-BROMO-2-CHLORO-3-PYRIDINAMINE;5-BROMO-2-CHLORO-PYRIDIN-3-YLAMINE;5-BROMO-2-CHLOROPYRIDIN-3-AMINE;3-AMINO-5-BROMO-2-CHLOROPYRIDINE;2-Chloro-3-amino-5-bromopyridine;3-Amino-5-bromo-2-chloropyridi;3-Amino-5-Bromo-2-Chloropyrid;6-(4-fluorophenyl)-2-hydroxynicotinonitrile
- Categories:
-
CAS No:
Safety Information
IRRITANT
2811
3
25-37/38-41-22
26-39-45
Xi,T
Irritant
P261-P280-P301 + P310-P305 + P351 + P338
H301-H315-H318-H335
2-Chloro-3-amino-5-bromopyridine Use and Manufacturing
Step 1: a) 3 -amino-5 -bromo-2-chloropyridineTo a stirred suspension of 5-bromo-2-chloro-3-nitropyridine (20.0 g, 84.2 mMol) in cone. HCl (90 mL) was added SnClTo a stirred suspension of 5-bromo-2-chloro-3-nitropyridine (84.2 mmol) in cone. HCl (90 rtiL) was added SnClTo a solution of 5-bromo-2-chloro-3-nitropyridine (4.24 g, 17.86 mmol) in EtOH (89 ml) was added Tin(II) chloride (16.9 g, 89.0 mmol) at room temperature. The mixture was refluxed for 1 hour, and then cooled to room temperature, filtered through a Celite pad and washed with EtOAc. The filtrate was concentrated in vacuo. The residue was treated with saturated aq. NaHCOIntermediate 3; Preparation of 2-amino-N, N-dimethyl-5-(4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolan-2-yl)-3-pyridinesulfonamide ; To a solution of 2-amino-5-bromo-N, N-dimethyl-3-pyridinesulfonamide (7.14 mmol) in 1, 4-dioxane (35 mL) was added 4, 4, 4', 4', 5, 5, 5', 5'-octamethyl-2, 2'-bi-1, 3, 2-dioxaborolane (7.86 mmol), potassium acetate (28.56 mmol) and [1, 1'-bis(diphenylphosphino)-ferrocene]dichloropalladium(II) dichloromethane complex (1:1) (0.571 mmol). The reaction mixture was stirred at 100° C. for 18 h. The reaction was concentrated in vacuo, re-dissolved in ethyl acetate (50 mL) and purified on silica using 60percent ethyl acetate/hexanes to yield the title compound as a tan solid (86percent).
Recommended Suppliers of 2-Chloro-3-amino-5-bromopyridine
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
4 YRS
Business licensed Certified factoryManufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive -
![China]()
CN
5 YRS
Business licensedTrader Supplier of Peptides,Chemicals,API,Additives
Learn More Other Chemicals
-
(2E)-3-(1-METHYL-1H-PYRROL-2-YL)ACRYLIC ACID
51485-76-8
-
Benadryl N-oxide hydrochloride
13168-00-8
-
6-CHLORO-3-IODO-IMIDAZO[1,2-A]PYRIDINE
885275-59-2
-
(2-Bromophenyl)diphenylphosphine Formula
62336-24-7
-
1-Morpholinocyclopentene Formula
936-52-7
-
4-[2-(Boc-amino)ethoxy]-benzoic acid Formula
168892-66-8
-
3-amino-5-bromopyridine-2-carboxylic acid Structure
870997-85-6
-
2-Amino-6-methylpyridine Structure
1824-81-3
-
What is 3-Bromo-2-methylthiophene
30319-05-2
-
What is THIOPHEN-2-YLMETHYL-PHOSPHONICACIDDIETHYLESTER
2026-42-8
2-Chloro-3-amino-5-bromopyridine
SDSRequest for Quotation