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Ascomycin

Ascomycin structure

CAS No:
104987-12-4
Formula:
C43H69NO12
Chemical Name:
Ascomycin
Synonyms:
15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-,(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-,[3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone;FR 900520;L 683590;FR 520;FK 520;Ascomycin;Immunomycin;Changchuanmycin;126340-36-1;133876-12-7;136457-58-4;137767-75-0;11011-38-4;148400-02-6;159430-76-9
Categories:
Analytical Chemistry > Standard

Description

White SolidChEBI: A macrolide that is produced by the fermentation of Streptomyces hygroscopicus and exhibits strong immunosuppressant properties.

Ascomycin Basic Attributes

Molecular Weight：

792.01

Exact Mass：

792.01

EC Number：

200-835-2

HScode：

29419090

Characteristics

PSA：

178.36000

XLogP3：

3.81

Appearance：

White Solid

Density：

1.19±0.1 g/cm3(Predicted)

Melting Point：

153-157°C

Boiling Point：

868℃

Flash Point：

>110°(230°F)

Refractive Index：

1.546

Water Solubility：

Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water

Storage Conditions：

−20°C

Safety Information

Transport codes：

UN 1648 3 / PGII

wgk germany：

hazard class code：

20/21/22-36-11

safety instructions：

36/37-16

RTECS Number：

KD4185000

Marks：

Xn,F

Precautionary statement(s)：

P210-P305 + P351 + P338

Hazard Statements：

H225-H302 + H332-H319

Ascomycin Use and Manufacturing

Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.

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CAS No.: 104987-12-4

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Ascomycin CAS No.104987-12-4

CAS No.: 104987-12-4

Grade: Pharmaceutical grade

Content: 99%

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