(3-(aminomethyl)phenyl)methanol

To 3-(difluoromethyl)-i -methyl- 1H-pyrazole-4- carboxylic acid (1.5 g, 8.52 mmol) was added dropwise 20 mE sulthryl dichloride, and then heated to reflux for 3 h, the excessive sulfuryl dichloride was evaporated under reduced pressure to get 3-(difluoromethyl)-i -methyl- 1H-pyrazole-4- carbonyl chloride, and then the carbonyl chloride was dissolved in 30 mE dichloromethane for the following reaction. To a cooled solution of 3-Aminomethylbenzyl alcohol (1.12 g, 8.2 mmol) was weighed into a 100 mL round bottom flask, Tetrahydrofuran (10 mL) was added and triethylamine (0.873 mL, 6.2 mmol) was added to the reaction mixture.Trifluoroacetic anhydride (0.897 mL, 6.2 mmol) was added dropwise under ice-cooling, Dropping process continued for about 30min, dropping to room temperature after stirring the reaction 3.5h, The progress of the reaction was monitored by TLC. After the reaction was completed, Adding ethyl acetate and water according to a volume of 1: 1 composition of the mixture was extracted, After the organic phase was washed with saturated ammonium chloride solution, After drying over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure at 37 C, Purification by silica gel column chromatography, eluent ethyl acetate and petroleum ether, With gradient elution, The volume ratio of ethyl acetate / petroleum ether gradually increased from 1: 1 to 1: 2, Drying in vacuo at 37 C gave 2, 2, 2-trifluoro-N- (3- (hydroxymethyl) benzyl) acetamide (1.54 g, 6.56 mmol) in 80% yield.

Molecular Weight:137.18
XLogP3:0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:137.084063974
Monoisotopic Mass:137.084063974
Topological Polar Surface Area:46.2
Heavy Atom Count:10
Complexity:95.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes