Methanone, (2-amino-5-chlorophenyl)phenyl-, oxime

yellow crystalline powder2-Amino-5-Chlorobenzophenone is in the form of a yellow-brown crystalline powder. Its melting point is 98-100°C. It is used to produce intermediates for the synthesis of Oxazolam drug and intermediates for psychotherapeutic agents, such as chlorodiazepoxide and diazepam.

Prepared by the reaction of 2-amino-5-chlorobenzophenone and hydroxylamine hydrochloride. After the ring-opening and reduction of isoxazole, the reactant of 2-amino-5-chlorobenzophenone was adjusted to pH 8 by adding liquid alkali, and then activated carbon was refluxed for 30 min, and filtered while hot. The filtrate was added with hydroxylamine hydrochloride and refluxed for 10h. After recovering the ethanol (75%), dilute with water to the ethanol concentration of 4-5%. Cool to 30°C and add a saturated solution of sodium carbonate to pH9. Filter, wash the cake with hot water until neutral. Filter dry, dry below 80 ℃, to obtain 2-amino-5-chlorobenzophenone oxime.

Intermediate in the preparation of Chlordiazepoxide (C327050) and its metabolites.

Molecular Weight:246.69
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:246.0559907
Monoisotopic Mass:246.0559907
Topological Polar Surface Area:58.6
Heavy Atom Count:17
Complexity:277
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes