 Home > Encyclopedia > 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide structure

CAS No:
36707-00-3
Formula:
C13H15N5O6
Chemical Name:
4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide
Synonyms:
4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide;4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide;API-1;NSC 177223;4-amino-8-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
Categories:
Biochemical Engineering > Saccharides

Request for Quotation

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Basic Attributes

Molecular Weight：

337.2881

Exact Mass：

337.102233 g/mol

NSC Number：

177223

DSSTox ID：

DTXSID40306513

Characteristics

PSA：

185 Å²

XLogP3：

-1.63440

Density：

1.792g/cm3

Boiling Point：

795.8ºC at 760 mmHg

Flash Point：

435.1ºC

Refractive Index：

1.764

Storage Conditions：

Store at RT

Safety Information

Precautionary statement(s)：

P301 + P310 + P330

Hazard Statements：

H301

Drug Information

MeSH Entry Terms：

API-1 compound

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Use and Manufacturing

NSC 177223 is a Akt/protein kinase B inhibitor. It binds to pleckstrin homologous domain of Akt and blocks Akt membrane translocation. Treatment of cancer cells with NSC 177223 results in inhibition of the kinase activities and induction of cell growth arrest and apoptosis selectively in human cancer cells that harbor constitutively activated Akt.

Computed Properties

Molecular Weight:337.29
XLogP3:-1.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:3
Exact Mass:337.10223322
Monoisotopic Mass:337.10223322
Topological Polar Surface Area:185
Heavy Atom Count:24
Complexity:571
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Learn More Other Chemicals

5'-deoxy-5'-thioinosine 5'-monophosphate

21959-63-7
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone

22003-30-1
5'-azacytidine5'-monophosphate

2226-72-4
Decarboxylated AdoMet Formula

22365-13-5
2′-Deoxy-6-thioinosine Formula

2239-64-7
Quercetin 3-glucuronide Formula

22688-79-5
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(methylamino)pyrimidin-2-one Structure

22882-02-6
Sucrose Structure

57-50-1
What is C18Dihydroceramide

2304-80-5
What is [5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl adamantane-1-carboxylate

23113-01-1

Hot Searches: valproate sodium; acid capric; butan-2-ol; bromobenzene; sf6 compound name; chlorphenamine

Guide of 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.