Bischloroanthrabenzoxocinone

Bischloroanthrabenzoxocinone ((-)BABX) is a selective inhibitor of Type II fatty acid synthesis (FASII). BABX showed IC50 values of 11.4 and 35.3 μg/ml in the S. aureus and E. coli FASII assays, respectively, with comparable antibacterial activities. FASII is essential to bacterial cell viability and is a promising target for the development of novel antibiotics. More recently, BABX has been shown to inhibit agonist binding to Liver X receptors (LXR). These receptors regulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol from cells.

Molecular Weight:391.2
XLogP3:7.3
Hydrogen Bond Acceptor Count:2
Exact Mass:390.0214350
Monoisotopic Mass:390.0214350
Topological Polar Surface Area:26.3
Heavy Atom Count:27
Complexity:669
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes