4-BROMO-1-TRITYL-1H-PYRAZOLE

A 500 mL Schlenk flask backfilled with NA solution of 150 g (1.0 mol) of 4-bromo-1H-pyrazole, 334 g (1.2 mol, 1.2 eq.) of trityl chloride, 158 g (2.0 mol, 2.0 eq.) of pyridine and 6.1 g (0.05 mol, 5 mol percent) of 4-dimethylaminopyridine in 2 L of dichloromethane was stirred at room temperature for 16 h. Manufacturing Example 32-1-1 4-Bromo-1-trityl-1H-pyrazole; To a solution of 4-bromopyrazole (10.0 g, 68.0 mmol) in N, N-dimethylformamide (100 mL) was added dropwise triethylamine (23.7 mL, 170 mmol) under nitrogen atmosphere at room temperature. Trityl chloride (37.9 g, 136 mmol) was added to the reaction solution on an ice bath (0° C.), and stirred for 3 hours at 70° C. Water (400 mL) was added to the reaction solution to precipitate the solids. The precipitated solids were filtered and dried under a reduced pressure. The solids were then azeotropically dried with toluene to obtain the title compound (22.9 g, 87percent).To a solution of 4-bromopyrazole (10.0 g, 68.0 mmol) in N, N-dimethylformamide (100 mL) was added dropwise triethylamine (23.7 mL, 170 mmol) under nitrogen atmosphere at room temperature. Trityl chloride (37.9 g, 136 mmol) was added to the reaction solution on an ice bath (0° C.), and stirred for 3 hours at 70° C. Water (400 mL) was added to the reaction solution to precipitate the solids. The precipitated solids were filtered and dried under a reduced pressure. The solids were then azeotropically dried with toluene to obtain the title compound (22.9 g, 87percent).

Molecular Weight:389.3
XLogP3:5.7
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:388.05751
Monoisotopic Mass:388.05751
Topological Polar Surface Area:17.8
Heavy Atom Count:25
Complexity:363
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes