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4-CHLORO-3-IODOANILINE

4-CHLORO-3-IODOANILINE structure

CAS No:
573764-31-5
Formula:
C6H5ClIN
Chemical Name:
4-CHLORO-3-IODOANILINE
Synonyms:
4-CHLORO-3-IODOANILINE;4-Chloro-3-iodoaniline 97%;BenzenaMine, 4-chloro-3-iodo-;4-Chloro-3-iodo-phenylamine;4-Chloro-3-iodoaniline97%
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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4-CHLORO-3-IODOANILINE Basic Attributes

Molecular Weight：

253.47

Exact Mass：

252.91600

HScode：

2921420090

Characteristics

PSA：

XLogP3：

2.9

Density：

2.016 g/cm3

Melting Point：

70 °C

Boiling Point：

322.3°C at 760 mmHg

Flash Point：

148.72ºC

4-CHLORO-3-IODOANILINE Use and Manufacturing

2) A mixture of compound 2 (10 mmol), iron powder (30 mmol) and saturated NHA 25 mL two-necked round bottom flask was fitted with condenser. Initially 0.1 g substrate (0.001 mol) was added to the flask followed by 10 mL solvent. After this 0.28 g iodine (0.001 mol) was added to the same flask followed by addition of 0.02 g catalyst. The reaction was carried out at different temperatures (Table 1) for 2-6 hrs. After completion of the reaction, 5 mL water was added to the reaction flask to stop the reaction. The reaction was monitored by GC analysis.In a microwave reaction vial with a magnetic stir bar, 2-chloro-4-(methylsulfonyl)benzoic acid (8) (235 mg, 1 mmol) was added into 10 mL SOCl2, and then reflux for 2h, removed the solvents and added 2 mL DMAc. The mixture was added dropwise with a solution of product 3 (203 mg, 0.8 mmol) in DMAc (2 mL) and stirred 40 min at 40°C . After the addition was complete, the mixture was added EtOAc (10 mL), washing with water (3 x 10 mL). The organic layer was dried over anhydrous sodium sulfate. The sample was concentrated and purified by silica gel column chromatography to obtain 1.45 g of product 10a (yield: 69percent). The synthesis route of (Entity 10b) was similar to 10a, and the delicate difference was replacing of 3 with 4.

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CAS No.: 573764-31-5

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CAS No.: 573764-31-5

Grade: pharmaceutical grade

Content: 98%

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