Chlormerodrin
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Chlormerodrin
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CAS No:
62-37-3
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Formula:
C5H11ClHgN2O2
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Chemical Name:
Chlormerodrin
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Synonyms:
Mercury,[3-[(aminocarbonyl-κO)amino]-2-methoxypropyl-κC]chloro-;Mercury,chloro(2-methoxy-3-ureidopropyl)-;Mercury,[3-[(aminocarbonyl)amino]-2-methoxypropyl-C1,O3]chloro-;Urea,[3-(chloromercuri)-2-methoxypropyl]-;Urea,(2-methoxypropyl)-,mercury complex;[3-[(Aminocarbonyl-κO)amino]-2-methoxypropyl-κC]chloromercury;Chlormerodrin;Chlormerodrine;Katonil;Mercoral;Mercloran;[3-(Chloromercuri)-2-methoxypropyl]urea;Neohydrin;Oricur;Promeran;Promerane;Percapyl;Neogidrin;Merilid;Mercardox;Merculest;Diurone;Chlormeroprin;NSC 19911;98139-26-5
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CAS No:
Description
Solid
Solid
Chlormerodrin is urea in which one of the hydrogens is substituted by a 3-chloromercury-2-methoxyprop-1-yl group. It was formerly used as a diuretic, but more potent and less toxic drugs are now available. Its radiolabelled ((197)Hg, (203)Hg) forms were used in diagnostic aids in renal imaging and brain scans. It has a role as a diuretic and a diagnostic agent. It is an organomercury compound and a member of ureas.|Chlormerodrin is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs.|A mercurial compound that has been used as a diuretic but is now superseded by more potent and less toxic drugs. The radiolabeled form has been used as a diagnostic and research tool.
Characteristics
64.4
-0.80
Solid
152.5 °C
2.92e+01 g/L
Oral-Rat LD50: 150 mg/kg; Oral-Mouse LD50: 215 mg/kg
Safety Information
OW1050000
The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials
Toxicity
highly toxic
As chlormerodrin has been shown to increase the levels of mercury in the kidney to toxic levels, any symptoms of overdose will most likely correspond to symptoms experienced in exposure to mercury.
Drug Information
Previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool.
Chlormerodrin is a mercurial compound with toxic side effects. It is no longer used and has been replaced with new classes of diuretic drugs.
Chlormerodrin most likely acts by a direct renal action. Mercurial diuresis is presumed to occur through inhibition of reabsorption of water and electrolytes in the convoluted tubules, although the problem of whether the locus of action is primarily on the proximal or distal portion has not yet been settled. There is also evidence that mercurials interfere with the permeability of the membrane of tubular cells by increasing passive influx of Na+ ion, Cl- ion and water into the cells, without interfering with the active extrusion of Na+ ion. Lastly, there is some evidence that chlormerodrin inhibits succinic dehydrogenase, but the clinical significance of this binding is not known.
3 Chloromercuri 2 methoxypropylurea
Computed Properties
Molecular Weight:367.20
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:368.021549
Monoisotopic Mass:368.021549
Topological Polar Surface Area:64.4
Heavy Atom Count:11
Complexity:125
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes