5-CHLOROISOINDOLIN-1-ONE

A suspension of copper (I) iodide (88 mg, 0.46 mmol), l-(3-bromophenyl)ethan-l-ol (1.85 g, 9.19 mmol) potassium carbonate (0.65 g, 4.59 mmol) and 5-chloroisoindolin-l-one (0.77 g, 4.59 mmol) in anhydrous A' A'-d i m e th y 1 fo rm am i dc (3.8 mL) was purged with nitrogen and heated at 150 C for 16 h. The mixture was diluted with 10% ammonium hydroxide solution. General Work-up Procedure 1 was followed. The residue was purified on silica gel (ethyl acetate in hexanes 40% isocratic) to give the title compound as an off-white solid. Yield: 0.42 g (32%).A mixture of In a 25 mL sealed tube, [A] 2-(8-Amino-5, 6, 7, 8-tetrahydro-isoquinolin-4-yl)-

Molecular Weight:167.59
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:167.0137915
Monoisotopic Mass:167.0137915
Topological Polar Surface Area:29.1
Heavy Atom Count:11
Complexity:183
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes