Sphingosine-1-phosphate
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Sphingosine-1-phosphate
structure -
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CAS No:
26993-30-6
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Formula:
C18H38NO5P
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Chemical Name:
Sphingosine-1-phosphate
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Synonyms:
4-Octadecene-1,3-diol,2-amino-,1-(dihydrogen phosphate),(2S,3R,4E)-;4-Octadecene-1,3-diol,2-amino-,1-(dihydrogen phosphate),(E)-D-erythro-;4-Octadecene-1,3-diol,2-amino-,1-(dihydrogen phosphate),[R-[R*,S*-(E)]]-;Sphingosine 1-phosphate;D-erythro-Sphingosine-1-phosphate;C18-Sphingosine 1-phosphate;Sphingosine-1-phosphate;S1P;Proteins,S1P;S1P protein;26993-39-5
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CAS No:
Description
Off-White to Grey Powder
Solid
Sphingosine 1-phosphate is a phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1 It has a role as a vasodilator agent, a sphingosine-1-phosphate receptor agonist, a signalling molecule, a T-cell proliferation inhibitor and a mouse metabolite. It derives from a sphingosine. It is a conjugate acid of a sphingosine 1-phosphate(1-).|Sphingosine 1-Phosphate is a bioactive sphingolipid comprised of a sphingosine with a phosphate group attached to the carbon at position 1. Sphingosine 1-phosphate (S1P) binds to G protein-coupled S1P receptors (S1PRs) and initiates signaling pathways involved in the regulation of angiogenesis, the proliferation of skin cells, vascular stability and permeability, and T- and B-cell trafficking.
Characteristics
113
5.46
yellow waxy solid
1.1±0.1 g/cm3
>200 °C
548.8±60.0 °C at 760 mmHg
285.7±32.9 °C
1.501
methanol: THF: water (6:3:1): >0.5 mg/mL
−20°C
2.49E-14mmHg at 25°C
Safety Information
NONH for all modes of transport
3
36/37/38
26-36
RG2260500
Xi
Moisture, Temperature Sensitive; Hygroscopic
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Sphingosine-1-phosphate Use and Manufacturing
A ligand for EDG-1 and EDG-3 and activator of GPR3, GPR6, and GPR12.
Lipids -> Sphingolipids [SP] -> Sphingoid bases [SP01] -> Sphingoid base 1-phosphates [SP0105]
Computed Properties
Molecular Weight:379.5
XLogP3:1.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:17
Exact Mass:379.24876031
Monoisotopic Mass:379.24876031
Topological Polar Surface Area:113
Heavy Atom Count:25
Complexity:373
Defined Atom Stereocenter Count:2
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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