4′,6-Diamidino-2-phenylindole
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4′,6-Diamidino-2-phenylindole
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CAS No:
47165-04-8
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Formula:
C16H15N5
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Chemical Name:
4′,6-Diamidino-2-phenylindole
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Synonyms:
1H-Indole-6-carboximidamide,2-[4-(aminoiminomethyl)phenyl]-;2-[4-(Aminoiminomethyl)phenyl]-1H-indole-6-carboximidamide;4′,6-Diamidino-2-phenylindole;DAPI;102/198;Antifade;97230-48-3
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CAS No:
Description
DAPI is a member of indoles. It has a role as a fluorochrome.|DAPI is a lipid soluble fluorochrome dye that binds to adenine-thymine (A-T) rich regions in DNA and, to a lesser extent, RNA. During fluorescence microscopy and flow cytometry, this agent binds to and detects endogenous and exogenous DNA in cellular samples. DAPI is excited with ultraviolet (UV) light (maximum absorption at 358 nm) and upon binding, emits light in the blue portion of the spectrum (461 nm for DNA and ~500 nm for RNA).
Drug Information
Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. (See all compounds classified as Fluorescent Dyes.)|Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA. (See all compounds classified as Intercalating Agents.)|Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES. (See all compounds classified as Serine Proteinase Inhibitors.)|Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA. (See all compounds classified as Trypanocidal Agents.)
4',6-diamidino-2-phenylindole
Computed Properties
Molecular Weight:277.32
XLogP3:1.6
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:277.13274550
Monoisotopic Mass:277.13274550
Topological Polar Surface Area:116
Heavy Atom Count:21
Complexity:413
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes