 Home > Encyclopedia > 6-Chloro-3-methyl-2,4(1H,3H)-pyrimidinedione

6-Chloro-3-methyl-2,4(1H,3H)-pyrimidinedione

6-Chloro-3-methyl-2,4(1H,3H)-pyrimidinedione structure

CAS No:
4318-56-3
Formula:
C5H5ClN2O2
Chemical Name:
6-Chloro-3-methyl-2,4(1H,3H)-pyrimidinedione
Synonyms:
2,4(1H,3H)-Pyrimidinedione,6-chloro-3-methyl-;Uracil,6-chloro-3-methyl-;6-Chloro-3-methyl-2,4(1H,3H)-pyrimidinedione;6-Chloro-3-methyluracil;3-Methyl-6-chlorouracil;6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione;NSC 55976;6-Chloro-3-methylpyrimidine-2,4-dione;6-Chloro-2-hydroxy-3-methylpyrimidin-4(3H)-one
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Request for Quotation

Description

White solid

6-Chloro-3-methyl-2,4(1H,3H)-pyrimidinedione Basic Attributes

Molecular Weight：

160.56

Exact Mass：

160.56

EC Number：

1308068-626-2

NSC Number：

55976

DSSTox ID：

DTXSID00195763

HScode：

2933599090

Characteristics

PSA：

49.4

XLogP3：

Density：

1.5±0.1 g/cm3

Melting Point：

277-279 °C

Boiling Point：

225.3°C at 760 mmHg

Refractive Index：

1.581

Safety Information

Transport codes：

UN 1992

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Hazard note：

Irritant

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 49 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

6-Chloro-3-methyl-2,4(1H,3H)-pyrimidinedione Use and Manufacturing

Methods of Manufacturing

Water (2.7 mL) is added dropwise to a suspension of 1 -methylpyrimidine-2, 4, 6(lH, 3//, 5H)-trione (14.2 g, 100 mol) in POCl(b) 6-Chloro-3-methylpyrimidine-2, 4(l/J, 3H)-dioneWater (2.7 mL) is added dropwise to a suspension of 1-methylpyrimidine- 2, 4, 6(lH, 3H, 5No.)-trione (14.2 g, 100 mol) in POClWater (2.7 mL) is added dropwise to a suspension of 1-methylpyrimidine-2, 4, 6(lH, 3H, 5H)-trione (14.2 g, 100 mol) in POCl1-methylpyrimidine-2, 4, 6-trione (80 g, 0.564 mol), Phosphorus oxychloride 400g, Cooling to 0°C, Control temperature is 05°C, stir for 0.5h, Warming to 60 °C reaction 1h.The excess phosphorus oxychloride is distilled off under reduced pressure.Cool down to 05°CAdded to 200 mL of methanol, Stirred for 1 h.Suction filtrationwashing, Dry to light yellow powder 3-methyl-6-chlorouracil 63.4g, yield70percent

Uses

6-Chloro-3-methyluracil have been used in the synthesis of antibacterial agents as inhibitors of Helicobacter pylori glutamate racemase.

Computed Properties

Molecular Weight:160.56
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:160.0039551
Monoisotopic Mass:160.0039551
Topological Polar Surface Area:49.4
Heavy Atom Count:10
Complexity:224
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 6-Chloro-3-methyl-2,4(1H,3H)-pyrimidinedione

Greenbo Biochem Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides,Organic Intermediates,OLED Intermediates

6-Chloro-3-methyluracil 99% Powder Professional Producer Greenbo

CAS No.: 4318-56-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

6-Chloro-3-methyluracil for Alogliptin Benzoate Intermediates

CAS No.: 4318-56-3

Inquiry
Nanjing CHICO Pharmaceutical Co., Ltd Contact Supplier

CN
8 YRS

Business licensed Certified factory

Manufactory Supplier of Anti-tumor categories,Cardiovascular,Anti-Diabetes Class

6-Chloro-3-methyluracil 99%

CAS No.: 4318-56-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Xian ZB Biotech Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Herb Extracts,Cosmetic raw materails,API

High Quality API Powder 6-Chloro-3-Methyluracil (CAS4318-56-3)

CAS No.: 4318-56-3

Content: 99%

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

6-Chloro-3-methyluracil4318-56-3

CAS No.: 4318-56-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry

Latest News on 6-Chloro-3-methyl-2,4(1H,3H)-pyrimidinedione

Learn More Other Chemicals

(2E)-3-(1-METHYL-1H-PYRROL-2-YL)ACRYLIC ACID

51485-76-8
Benadryl N-oxide hydrochloride

13168-00-8
6-CHLORO-3-IODO-IMIDAZO[1,2-A]PYRIDINE

885275-59-2
(2-Bromophenyl)diphenylphosphine Formula

62336-24-7
1-Morpholinocyclopentene Formula

936-52-7
4-[2-(Boc-amino)ethoxy]-benzoic acid Formula

168892-66-8
3-amino-5-bromopyridine-2-carboxylic acid Structure

870997-85-6
2-Amino-6-methylpyridine Structure

1824-81-3
What is 3-Bromo-2-methylthiophene

30319-05-2
What is THIOPHEN-2-YLMETHYL-PHOSPHONICACIDDIETHYLESTER

2026-42-8

Hot Searches: cl2o7; smz tmp drug; disodium pyrophosphate; 2-chlorobenzoic acid; dichloromethane density; 2 pentanol

Guide of 6-Chloro-3-methyl-2,4(1H,3H)-pyrimidinedione

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
Learn More Other Chemicals

6-Chloro-3-methyl-2,4(1H,3H)-pyrimidinedione

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.