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(αS)-7-Fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine

(αS)-7-Fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine structure

CAS No:
1608125-21-8
Formula:
C21H16FN7
Chemical Name:
(αS)-7-Fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine
Synonyms:
3-Quinolinemethanamine,7-fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-,(αS)-;(αS)-7-Fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine;AMG 319;N-[(1S)-1-[7-Fluoro-2-(2-pyridinyl)-3-quinolinyl]ethyl]-9H-purin-6-amine;ACP 319;1395408-86-2
Categories:
Biochemical Engineering > Saccharides

Description

PI3K-delta Inhibitor AMG 319 is a highly selective, potent, and orally bioavailable small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. PI3K-delta inhibitor AMG 319 prevents the activation of the PI3K signaling pathway through inhibition of the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), thus decreasing proliferation and inducing cell death. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.

(αS)-7-Fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine Basic Attributes

Molecular Weight：

385.41

Exact Mass：

385.40

UNII：

19DG7G1U5Q

NCI Thesaurus Code：

C95891

Characteristics

PSA：

92.3 Å²

XLogP3：

4.34830

Appearance：

crystalline solid

Density：

1.432±0.06 g/cm3(Predicted)

Boiling Point：

708.3±60.0 °C(Predicted)

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

ACP-319

Computed Properties

Molecular Weight:385.4
XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:385.14512170
Monoisotopic Mass:385.14512170
Topological Polar Surface Area:92.3
Heavy Atom Count:29
Complexity:551
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of (αS)-7-Fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine

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AMG319

CAS No.: 1608125-21-8

Content: 99.00%

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Guide of (αS)-7-Fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Recommended Suppliers
Learn More Other Chemicals

(αS)-7-Fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine

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