Detomidine
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Detomidine
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CAS No:
76631-46-4
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Formula:
C12H14N2
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Chemical Name:
Detomidine
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Synonyms:
1H-Imidazole,5-[(2,3-dimethylphenyl)methyl]-;1H-Imidazole,4-[(2,3-dimethylphenyl)methyl]-;5-[(2,3-Dimethylphenyl)methyl]-1H-imidazole;Detomidine;MPV 252AII
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CAS No:
Description
Detomidine is an α2-adrenergic agonist that is used as a horse sedative. Normally, it is administered in the salt form, detomidine hydrochloride. This drug is prescribed by veterinarians and is marketed as Dormosedan. Currently, it is only approved by the FDA for use in horses but has been studied for use in other large animals.
Characteristics
28.68000
2.61730
White crystalline powder
1.077±0.06 g/cm3
114-116 °C
386.5±11.0 °C(Predicted)
200.6ºC
1.582
LD50 i.v. in mice: 35 mg/kg (Karjalayne, Kurkela)
14.44±0.10
146.8 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]
Drug Information
Used as a large animal sedative, primarily in horses.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)|Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)|Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)
detomidine
Computed Properties
Molecular Weight:186.25
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:186.115698455
Monoisotopic Mass:186.115698455
Topological Polar Surface Area:28.7
Heavy Atom Count:14
Complexity:181
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes