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(2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile,hydrochloride

(2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile,hydrochloride structure

CAS No:
134665-72-8
Formula:
C10H13ClN4O4
Chemical Name:
(2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile,hydrochloride
Synonyms:
CNDAC hydrochloride; 2'-Cyano-2'-deoxyarabinofuranosylcytosine; (2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile hydrochloride;
Categories:
Biochemical Engineering > Saccharides

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Description

Radgocitabine Hydrochloride is the hydrochloride salt form of radgocitabine, an analogue of the nucleoside deoxycytidine with potential antineoplastic activity. Upon administration, radgocitabine is incorporated into DNA and directly inhibits the activity of DNA polymerase, which may result in inhibition of DNA replication and cell cycle arrest in the S and G2/M phases, DNA fragmentation, and tumor cell apoptosis.

(2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile,hydrochloride Basic Attributes

Molecular Weight：

288.68800

Exact Mass：

288.0625326

UNII：

VSS4ZDZ2IE

DSSTox ID：

DTXSID30158861

NCI Thesaurus Code：

C150430

Characteristics

PSA：

135.38000

XLogP3：

-0.63972

Boiling Point：

596.9ºC

Flash Point：

314.8ºC

Vapor Pressure：

9.77E-17mmHg at 25°C

Drug Information

MeSH Entry Terms：

2'-cyano-2'-deoxyarabinofuranosylcytosine

Computed Properties

Molecular Weight:288.69
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:288.0625326
Monoisotopic Mass:288.0625326
Topological Polar Surface Area:132
Heavy Atom Count:19
Complexity:466
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Guide of (2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile,hydrochloride

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Learn More Other Chemicals

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