Imipramine pamoate
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Imipramine pamoate
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CAS No:
10075-24-8
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Formula:
C23H16O6.2C19H24N2
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Chemical Name:
Imipramine pamoate
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Synonyms:
2-Naphthalenecarboxylic acid,4,4′-methylenebis[3-hydroxy-,compd. with 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine (1:2);2-Naphthoic acid,4,4′-methylenebis[3-hydroxy-,compd. with 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine (1:2);2-Naphthoic acid,4,4′-methylenebis[3-hydroxy-,compd. with 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine;5H-Dibenz[b,f]azepine,5-[3-(dimethylamino)propyl]-10,11-dihydro-,4,4′-methylenebis[3-hydroxy-2-naphthoate] (2:1);5H-Dibenz[b,f]azepine-5-propanamine,10,11-dihydro-N,N-dimethyl-,4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (2:1);Imipramine pamoate;22540-17-6
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CAS No:
Description
Imipramine Pamoate is the pamoate salt of imipramine, a synthetic dibenzazepine derivative with anti-depressant activity. Imipramine pamoate, a tricyclic antidepressant (TCA) potentiates the activity of adrenergic synapses by blocking the re-uptake of norepinephrine and serotonin, thereby preventing their degradation and increasing their availability. This drug also has antimuscarinic and anti-histamine properties, which contribute to its side effects.|The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
Imipramine pamoate Basic Attributes
949.18400
948.48258577 g/mol
233-206-6
MC34P30298
DTXSID80143484
C61788
Safety Information
|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P273, P301+P312, P307+P311, P321, P330, P391, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)|Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)
4,4'-Methylenebis(3-hydroxy-2-naphthoic acid)-3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethyl-1-propanamine (1:2)
Imipramine pamoate Use and Manufacturing
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:949.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:12
Exact Mass:948.48258577
Monoisotopic Mass:948.48258577
Topological Polar Surface Area:128
Heavy Atom Count:71
Complexity:859
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Learn More Other Chemicals
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Imipramine
50-49-7
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2-Hydroxy Imipramine β-D-Glucuronide
54190-76-0
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Imipramine hydrochloride
113-52-0
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Hydroxyzine pamoate Formula
10246-75-0
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Oxantel pamoate Formula
68813-55-8
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Pyrvinium pamoate Formula
3546-41-6
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Pyrantel pamoate Structure
22204-24-6
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Imipramine N-oxide Structure
6829-98-7
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What is Disodium pamoate
6640-22-8
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