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Hydroxyzine pamoate

Hydroxyzine pamoate structure

CAS No:
10246-75-0
Formula:
C23H16O6.C21H27ClN2O2
Chemical Name:
Hydroxyzine pamoate
Synonyms:
2-Naphthalenecarboxylic acid,4,4′-methylenebis[3-hydroxy-,compd. with 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol (1:1);2-Naphthoic acid,4,4′-methylenebis[3-hydroxy-,compd. with 2-[2-[4-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol (1:1);2-Naphthoic acid,4,4′-methylenebis[3-hydroxy-,hydroxyzine salt;Ethanol,2-[2-[4-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]-,4,4′-methylenebis[3-hydroxy-2-naphthoate] (1:1) (salt);Ethanol,2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-,4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (1:1);Hydroxyzine pamoate;Vistaril;1-(p-Chloro-α-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine,pamoate;Equipose;Masmoran;Paxistil;Atarax P;Hydroxyzyne pamoate;Paxisitil;Vistaril pamoate;2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol 4,4′-methylenebis(3-hydroxy-2-naphthoate)
Categories:
Analytical Chemistry > Standard

Description

Hydroxyzine pamoate is a histamine H1-receptor antagonist.Target: Histamine H1-ReceptorHydroxyzine inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min [1]. Hydroxyzine (0.1 mM) treatment inhibits the progression and severity of EAE by 50% and the extent of mast cell degranulation by 70% in Lewis rats with allergic encephalomyelitis (EAE) [2]. Hydroxyzine (500 M) significantly increases transport of et

A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.

Hydroxyzine pamoate Basic Attributes

Molecular Weight：

763.27

Exact Mass：

762.270813

EC Number：

233-582-1

NSC Number：

757063

HScode：

2933595960

Characteristics

PSA：

151

XLogP3：

7.32310

Density：

1.182g/cm3

Boiling Point：

499.2ºC at 760mmHg

Flash Point：

255.7ºC

Vapor Pressure：

2.13E-17mmHg at 25°C

Collision Cross Section：

195.4 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)|Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)

MeSH Entry Terms：

2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol

Hydroxyzine pamoate Use and Manufacturing

Uses

anxiolytic, antihistaminic

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:763.3
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:12
Exact Mass:762.2707940
Monoisotopic Mass:762.2707940
Topological Polar Surface Area:151
Heavy Atom Count:55
Complexity:945
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes