SKF 77434
-
SKF 77434
structure -
-
CAS No:
104422-04-0
-
Formula:
C19H21NO2
-
Chemical Name:
SKF 77434
-
Synonyms:
1H-3-Benzazepine-7,8-diol,2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-;1H-3-Benzazepine-7,8-diol,2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-;2,3,4,5-Tetrahydro-1-phenyl-3-(2-propen-1-yl)-1H-3-benzazepine-7,8-diol;SKF 77434;(±)-SKF 77434;148553-52-0
-
CAS No:
Description
N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol is a benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1, an allyl substituent at position 3 and two hydroxy substituents at positions 7 and 8. Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo. It has a role as a dopamine agonist. It is a benzazepine, a member of catechols and a tertiary amino compound. It is a conjugate acid of a N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepinium-7,8-diol(1+).
Drug Information
Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)
3-allyl-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Computed Properties
Molecular Weight:295.4
XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:295.157228913
Monoisotopic Mass:295.157228913
Topological Polar Surface Area:43.7
Heavy Atom Count:22
Complexity:366
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Learn More Other Chemicals
-
SKF 96365
130495-35-1
-
SKF 86466
73943-10-9
-
SKF 38393
67287-49-4
-
SKF 105992 Formula
132877-29-3
-
SKF 82958 Formula
80751-65-1
-
SKF 89976 Formula
85375-85-5